Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application

Fig. 3

The principal methods to measure chromatin accessibility. The free and occupied DNA are distinct in hypersensitive to MNase- and DNase-mediated cleavage, solubility in different solvents, DNA methylation, as well as transposase-mediated transposition. Combining with high-throughput sequencing, MNase-seq (a), DNase-seq (b), FAIRE-seq (c), NOMe-seq (d), and ATAC-seq (e) are widely used in genome-wide accessibility studies. This picture was drawn by Freescience

Back to article page