Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Epigenetics-targeted drugs: current paradigms and future challenges

Fig. 1

Epigenetic mechanisms and key examples of widely studied modifications and their modifying enzymes. a DNA modifications, histone modifications, RNA modifications, chromatin remodeling, and the regulation based on non-coding RNA constitute the core content of epigenetics, being responsible for passing on heritable variations of genetic information independently of the DNA sequence. b Epigenetic modifications are reversible progress catalyzed by functionally complementary modifying enzymes, which provide targets for disease therapeutics

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