Fig. 4
From: Epigenetics-targeted drugs: current paradigms and future challenges
The development direction and major categories of epigenetics-targeted drugs. a Epigenetics-targeted drugs are developed through the virtual screening of compound libraries, drug design based on molecular structure, and the exploration of potential mechanisms of known agents. Subsequently, applying PROTAC, CRISPR/Cas, and other technologies or mechanisms to optimize the physical properties, and inhibitory or agonistic effects of compounds. Finally, the druggability of possible agents should be improved in experimental, preclinical and clinical studies. b The classification of epigenetics-targeted drugs and their corresponding marketed representative agents are depicted in this section. Among them, epigenetics-targeted drugs that have already been approved and applied in clinical treatment are highlighted in corresponding colors
