Fig. 1
From: The molecular mechanisms of cardiac development and related diseases
Timeline of milestone events in cardiac development research history. Each significant breakthrough in cardiac development research has been accompanied by advancements in related disciplines and technologies. The research of cardiac development starting with early studies observing morphological changes to exploration of molecular mechanisms using various molecular biology methods. Nowadays, advancements in stem cell technology and sequencing technology, such as the generation of cardiac organoids and multi-omics sequencing, have enabled researchers to understand the molecular mechanisms of cardiac development better. AV atrioventricular; AVC atrioventricular canal, CHD congenital heart disease, GATA4 GATA binding protein 4, hPSCs human pluripotent stem cells, Isl1 islet 1, MERFISH multiplexed error-robust fluorescence in situ hybridization, Mesp1 mesoderm posterior 1, Nkx2-5 NK2 homeobox 5, OFT outflow tract, PE proepicardium, RA retinoic acid, SHF second heart field, Tbx18 T-box transcription factor 18. This figure was created using Microsoft Powerpoint
