Fig. 2
From: The molecular mechanisms of cardiac development and related diseases
The molecular mechanisms of cardiac development were explored using pluripotent stem cell technology and multi-omics analysis. Pluripotent stem cells are generated by reprogramming adult somatic cells from CHD patients or animal models into a pluripotent state. These cells can differentiate into various cardiac cells, such as cardiomyocytes, smooth muscle cells, endothelial cells, and epicardial cells, through different differentiation protocols. Pluripotent stem cells can also form cardiac organoids through self-organization and specific differentiation methods, thereby creating an in vitro model of cardiac development. Multiomics analysis encompasses genomics, transcriptomics, proteomics, epigenomics, and metabolomics. By analyzing heart tissues obtained from CHD patients or animal models or cells derived from pluripotent stem cells, multi-omics analysis can be used to investigate the molecular mechanisms involved in the regulation of cardiac development at multiple levels. CHD congenital heart disease. This figure was created using Adobe Illustrator
