Table 6 Current randomized trials of treatment of congenital heart diseases
From: The molecular mechanisms of cardiac development and related diseases
Treatment class | Conditions | Interventions | Start time | Status | Location | Identifier |
|---|---|---|---|---|---|---|
Procedural treatment | Tetralogy of Fallot/Pulmonary Valve Insufficiency/Ventricular Dysfunction, right | PROCEDURE: PVR plus RV remodeling/PROCEDURE: Standard PVR | 2004-04-01 | NA/Completed | United States | NCT00112320 |
Heart Defects, Congenital | PROCEDURE: Blalock-Taussig pulmonary artery shunt/PROCEDURE: Right ventricular to pulmonary artery shunt | 2005-05-01 | Phase III/Completed | United States/Canada | NCT00115934 | |
Congenital Heart Disease | PROCEDURE: Remote ischemic preconditioning | 2008-01-01 | Phase I&II/Completed | Brazil | NCT00868101 | |
Congenital Heart Disease | PROCEDURE: Norwood management strategy/PROCEDURE: Hybrid Strategy | 2010-03-01 | Phase III/Unknown | Canada | NCT01134302 | |
Heart Defects, Congenital | PROCEDURE: Remote Ischemic Preconditioning/OTHER: Control | 2011-09-01 | NA/Completed | United States | NCT01835392 | |
Hypogammaglobulinemia/Congenital Heart Disease | Drug: IVIG/Other: Placebo | 2014-05-01 | NA/Completed | United States | NCT02043379 | |
Congenital Heart Disease | Procedure: Surgery with CPB/Other: Fresh Frozen Plasma/Other: Plasmalyte | 2015-10-01 | NA/Completed | Belgium | NCT02567786 | |
Persistent Ductus Arteriosus | PROCEDURE: Surgical treatment/DRUG: Control group | 2015-10-01 | Phase II/Unknown | Mexico | NCT02602054 | |
Perimembranous Ventricular Septal Defect | PROCEDURE: transthoracic device closure/PROCEDURE: surgical repair | 2015-10-01 | Phase II&III/Unknown | China | NCT02644330 | |
Cardiac Surgery/Congenital Heart Defects/Cardiopulmonary Bypass | Drug: Dexamethasone/Drug: Placebo | 2015-12-01 | Phase III/Completed | Brazil/China/ Russian Federation | NCT02615262 | |
Heart Defects, Congenital | PROCEDURE: Right lateral position (2 hours)/PROCEDURE: Left lateral position (30 minutes)/PROCEDURE: Supine position (30 minutes)/PROCEDURE: Left lateral position (2 hours)/PROCEDURE: Supine position (2 hours) | 2016-01-30 | NA/Unknown | Egypt | NCT02622152 | |
Pulmonary Atresia with Ventricular Septal Defect/Tetralogy of Fallot with Pulmonary Atresia | PROCEDURE: Experimental: RVOT reconstruction by femoral allogenic vein valve conduit/PROCEDURE: Systemic-to-pulmonary artery shunts | 2016-05-05 | NA/Completed | Russian Federation | NCT02861963 | |
Coarctation of Aorta | PROCEDURE: Surgical repair of coarctation of aorta | 2016-07-01 | NA/Unknown | Russian Federation | NCT02835703 | |
Congenital Heart Disease/Oral Aversion | PROCEDURE: Endotracheal intubation | 2018-07-01 | United States | NCT05378685 | ||
Congenital Heart Disease | PROCEDURE: Paravertebral Nerve Block/DRUG: Standard of Care Anesthesia | 2018-07-18 | Phase IV/Recruiting | United States | NCT03408340 | |
Congenital Heart Disease/Mechanical Ventilation Complication/Cardiopulmonary Bypass | PROCEDURE: Ventilation during cardiopulmonary bypass | 2018-08-20 | NA/Unkown | Italy | NCT03629574 | |
Tetralogy of Fallot/Pulmonary Regurgitation | PROCEDURE: Pulmonary valve replacement | 2019-04-01 | NA/Recruiting | Denmark | NCT04084132 | |
Grown-up Congenital Heart Disease | PROCEDURE: Oxygen application/PROCEDURE: Sham room air | 2019-09-12 | NA/Completed | Switzerland | NCT04076501 | |
Heart Defects, Congenital | PROCEDURE: Ventricular septal defect closure surgery/PROCEDURE: Ventricular septal defect closure catheter | 2020-06-12 | NA/Completed | Egypt | NCT05306483 | |
Congenital Heart Disease | PROCEDURE: SC TAP/PROCEDURE: Control | 2021-01-15 | NA/Completed | Korea | NCT04570878 | |
Cardiac Septal Defects with Coarctation of the Aorta/Mitral Regurgitation | PROCEDURE: Ultrasound guided Pecto-intercostal- fascial plane block/PROCEDURE: Ultrasound guided erector spinae plane block/DRUG: Bupivacain | 2022-05-25 | Phase II/Completed | Egypt | NCT05475561 | |
Aortic Stenosis with Bicuspid Valve | PROCEDURE: TAVR for BAV Using Down Sizing with the Evolut Pro platform/PROCEDURE: TAVR for BAV Using Traditional Sizing strategy with the Evolut Pro platform | 2022-06-27 | NA/Recruiting | China | NCT05511792 | |
Congenital Heart Disease | PROCEDURE: Serratus anterior plane block/PROCEDURE: erector spinae plane blocks/DRUG: Bupivacaine 0.25% Injectable Solution | 2022-07-24 | NA/Completed | Egypt | NCT05526469 | |
Atrial Septal Defect/Ventricular Septal Defect/Pain, Procedural | PROCEDURE: Regional Anesthesia/PROCEDURE: Wound infiltration/DRUG: Ropivacaine 0.2% Injectable Solution | 2023-03-29 | Phase IV/Recruiting | United States | NCT05688670 | |
Transposition of Great Vessels/Tetralogy of Fallot/Truncus Arteriosus/Pulmonary Artery Stenosis Supravalvular Congenital/Stent Stenosis/Right Ventricular Dysfunction/Congenital Heart Disease | PROCEDURE: Percutaneous intervention (stent) for PA stenosis | 2023-04-18 | NA/Recruiting | Netherlands | NCT05809310 | |
Complex Congenital Heart Disease/Enhanced Recovery After Surgery | PROCEDURE: ERAS | 2023-07-01 | NA/Not yet recruiting | China | NCT05914103 | |
Congenital Heart Disease | PROCEDURE: Umbilical Cord Clamping at ~30 seconds/PROCEDURE: Umbilical Cord Clamping at ~120 seconds/PROCEDURE: Umbilical Cord Milking | 2023-12-19 | NA/Recruiting | United States/Canada | NCT06153459 | |
Congenital Heart Disease | PROCEDURE: Bilateral two-level serratus anterior block | 2024-02-10 | NA/Not yet recruiting | NCT06221150 | ||
Congenital Heart Disease | PROCEDURE: High Flow Nasal Canula following extubation/PROCEDURE: Non-Invasive Positive Pressure Ventilation following extubation | 2024-05-01 | NA/Not yet recruiting | United States | NCT05869825 | |
Pharmacological treatment | Turner Syndrome | DRUG: estrogen/DRUG: androgen/OTHER: placebo | 1992-11-01 | Phase III/Completed | United States | NCT00029159 |
Patent Ductus Arteriosus | DRUG: Continuous indomethacin/DRUG: ibuprofen | 2002-02-01 | Phase III/Completed | Israel | NCT00485160 | |
Cardiac output, low | Drug: Hydrocortisone/ Other: Placebo | 2003-02-01 | Phase II/Completed | United States | NCT00590018 | |
Heart Defects, Congenital/Heart Failure, Congestive | Drug: Enalapril/Drug: Placebo | 2003-08-01 | Phase III/Completed | United States | NCT00113087 | |
Transposition of Great Vessels/Congenital Heart Disease | DRUG: N-acetylcysteine/DRUG: Placebo | 2005-02-01 | Phase II/Completed | United States | NCT00374088 | |
Turner Syndrome | DRUG: estradiol | 2005-06-01 | Phase IV/Completed | Denmark | NCT00134745 | |
Turner Syndrome | DRUG: ZOMACTON | 2005-10-01 | Phase III/Completed | Czech Republic/France/Netherlands | NCT00250250 | |
Blood Loss/Congenital Heart Disease | DRUG: Tranexamic Acid | 2006-01-01 | NA/Completed | NCT00994994 | ||
Heart Defects, Congenital | Drug: Clopidogrel (SR25990)/ Drug: placebo | 2006-11-01 | Phase III/Completed | United States | NCT00396877 | |
Marfan Syndrome | DRUG: Losartan Potassium/DRUG: Atenolol | 2007-01-01 | Phase III/Completed | United States/Belgium/Canada | NCT00429364 | |
Congenital Heart Disease/Disorder of Fetus or Newborn | Drug: IVMP/Drug: two doses IVMP | 2007-03-01 | NA/Completed | United States | NCT00934843 | |
Turner Syndrome | DRUG: Growth Hormone/DRUG: Placebo/OTHER: Healthy controls | 2007-08-01 | NA /Completed | Denmark | NCT00420654 | |
Cerebral Oxygenation | DRUG: nitroprusside/DRUG: nitroglycerine/DRUG: sevoflurane | 2007-10-01 | Phase II /Completed | Belgium | NCT00535808 | |
Marfan Syndrome | DRUG: Atenolol/DRUG: Losartan | 2007-10-01 | Phase III /Completed | United States | NCT00723801 | |
Hypoplastic Left Heart Syndrome/Tricuspid Atresia | DRUG: Sildenafil/DRUG: Placebo | 2007-12-01 | Phase II /Completed | NCT00507819 | ||
Congenital Heart Disease | DRUG: Nitric Oxide | 2008-01-01 | Phase I&II /Completed | United States | NCT00585013 | |
Eisenmenger Syndrome | DRUG: Tadalafil, placebo | 2008-02-01 | Phase I /Completed | India | NCT01200732 | |
Eisenmenger Syndrome | DRUG: Bosentan and Sildenafil | 2006-03-01 | Phase III /Completed | Denmark | NCT00303004 | |
Patent Ductus Arteriosus | DRUG: Indomethacin/DRUG: Pentoxifylline | 2008-03-01 | Phase II/Unknown | Israel | NCT00616382 | |
Ductus Arteriosus, Patent | DRUG: Ibuprofen | 2008-06-01 | Phase II&III/Completed | Italy | NCT01243996 | |
Marfan Syndrome | DRUG: Losartan and nebivolol/DRUG: Losartan/DRUG: Nebivolol | 2008-07-01 | Phase III/Unknown | Italy | NCT00683124 | |
Congenital Cardiovascular Defects/Low Cardiac Output Syndrome | Drug: Levosimendan/Drug: Milrinone | 2008-07-01 | NA/Completed | Belgium | NCT00695929 | |
Transposition of Great Vessels/Atrial Switch Procedure | Drug: Eplerenone | 2008-07-01 | Phase IV/Completed | Spain | NCT00703352 | |
Marfan Syndrome | DRUG: Losartan/DRUG: Atenolol | 2008-10-01 | Phase III/Unknown | Spain | NCT01145612 | |
Tetralogy of Fallot /Ventricular Septal Defects /Atrioventricular Septal Defects | DRUG: Fentanyl (High Dose)/DRUG: Fentanyl (Low Dose)/DRUG: Fentanyl (Low Dose) + Dexmedetomidine | 2008-11-01 | Phase II/Completed | United States | NCT00848393 | |
Patent Ductus Arteriosus | DRUG: oral ibuprofen | 2009-01-01 | NA/Completed | Turkey | NCT01261117 | |
Patent Ductus Arteriosus | Drug: Ibuprofen EchoG/Drug: Standard ibuprofen treatment | 2009-05-01 | Phase III/Completed | Spain | NCT01593163 | |
Congenital Heart Disease | DRUG: moderate potassium group/DRUG: High potassium group | 2009-10-01 | NA/Completed | China | NCT01479049 | |
Low Cardiac Output Syndrome | DRUG: Milrinone/DRUG: Levosimendan | 2009-11-01 | Phase I&II/Completed | Spain | NCT01576094 | |
Marfan Syndrome | DRUG: Aliskiren/DRUG: Atenolol | 2010-06-01 | Phase III/Completed | Korea | NCT01715207 | |
Atrial Septal Defect/Ventricular Septal Defect/Atrioventricular Septal Defect | DRUG: Intravenous L-Citrulline/DRUG: Placebo of Intravenous L-Citrulline | 2010-09-01 | Phase I&II/Completed | United States | NCT01120964 | |
Heart Septal Defects, Atrial | DRUG: Bosentan/DRUG: Placebo | 2010-10-01 | Phase III/Completed | Belgium | NCT01218607 | |
Pediatric Ventricular Septal Defects | DRUG: sufentanil anesthesia/PROCEDURE: Hybrid closure/PROCEDURE: Control | 2011-01-01 | NA/Completed | NCT02794584 | ||
Hypoplastic Left Heart Syndrome/Tricuspid Atresia/Other Specified Congenital Anomalies of Heart | DRUG: Bosentan/DRUG: Placebo | 2011-02-01 | Phase II/Completed | Denmark/ Sweden | NCT01292551 | |
Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation | DRUG: Administration of an ACE-inhibitor or not | 2011-09-01 | Phase II/Completed | Belgium | NCT00263406 | |
Congenital Heart Disease | DRUG: Bosentan | 2011-09-01 | NA/Unknown | Netherlands | NCT01184404 | |
Congenital Heart Diseases | DRUG: Sevoflurane/OTHER: Control | 2011-09-01 | NA/Unknown | China | NCT01450956 | |
Patent Ductus Arteriosus | DRUG: Oral paracetamol/DRUG: Oral ibuprofen | 2012-02-01 | Phase IV/Completed | Turkey | NCT01536158 | |
Patent Ductus Arteriosus | DRUG: Ibuprofen/DRUG: Placebo | 2012-03-01 | Phase III/Completed | France | NCT01630278 | |
Heart Disease Congenital Complex | Drug: Hydrocortisone/Drug: Normal Saline | 2012-04-01 | NA/Completed | United States | NCT01595386 | |
Patent Ductus Arteriosus | DRUG: Paracetamol/DRUG: NSAID/DRUG: D5W | 2012-04-01 | Phase II/Unknown | Israel | NCT01291654 | |
Congenital Heart Disease/Disorder of Fetus or Newborn | DRUG: Methylprednisolone/DRUG: Placebo | 2012-06-01 | NA/Completed | United States | NCT01579513 | |
Pulmonary Hypertension | DRUG: iloprost nebulizer solution/DRUG: distilled water | 2012-06-01 | Phase III/Completed | China | NCT01598441 | |
Single Ventricle Fontan Palliation | DRUG: Ambrisentan | 2012-08-01 | Phase IV/Completed | United States | NCT01971580 | |
Congenital Heart Disease/Heart Valve Disease | DRUG: simvastatin | 2013-01-01 | NA/Recruiting | China | NCT01653223 | |
Congenital Heart Disease | DRUG: Milrinone | 2013-04-01 | Phase II/Completed | Canada | NCT01841177 | |
Pulmonary Arterial Hypertension | DRUG: Macitentan 10 mg/DRUG: Placebo | 2013-05-21 | Phase III/Completed | United States/ Austria /Bulgaria/Chile/China/France/Germany/ Greece/ Mexico/Poland/ Romania/ Russian Federation/ Serbia/ Spain/ United Kingdom/Turkey/ Vietnam | NCT01743001 | |
Alagille Syndrome | DRUG: LUM001/DRUG: Placebo | 2013-08-01 | Phase II/Completed | United Kingdom | NCT01903460 | |
Persistent Ductus Arteriosus/Complication of Prematurity/Pain or Discomfort in Intensive Care of Preterm Infants | DRUG: paracetamol/DRUG: 0.45% saline solution | 2013-08-01 | Phase II/Recruiting | Finland | NCT01938261 | |
Congenital Heart Defects/Tetralogy of Fallot | DRUG: recombinant human brain natriuretic peptide /DRUG: Placebo (0.9% sodium chloride) | 2013-09-01 | NA/Completed | China | NCT01941576 | |
Patent Ductus Arteriosus/Surgery/Necrotizing Enterocolitis/Intestinal Perforation | OTHER: pharmacologic treatment of the PDA/OTHER: no pharmacologic treatment of the PDA/DRUG: NSAID | 2013-12-01 | Phase II/Completed | United States | NCT01958320 | |
Tetralogy of Fallot/Heart Defects, Congenital/Ventricular Dysfunction, Right | DRUG: Losartan/DRUG: Placebo | 2013-12-01 | Phase II/Unknown | Netherlands | NCT02010905 | |
Congenital Heart Disease | DRUG: continuous infusion/DRUG: as needed dosing/DRUG: Acetaminophen/DRUG: ketorolac | 2014-06-01 | NA/Completed | United States | NCT02112448 | |
Ductus Arteriosus, Patent | DRUG: Paracetamol/DRUG: Placebo | 2014-08-01 | Phase II&III/Completed | Israel | NCT02002741 | |
Alagille Syndrome | DRUG: LUM001 (Maralixibat)/DRUG: Placebo | 2014-10-28 | Phase II/Completed | France/ Belgium/ Australia/ Spain/ United Kingdom | NCT02160782 | |
Congenital Heart Defects | Drug: Triostat/Drug: Placebo | 2014-11-01 | Phase III/Completed | United States | NCT02320669 | |
Alagille Syndrome | DRUG: LUM001/DRUG: Placebo | 2014-11-24 | Phase II/Completed | United States | NCT02057692 | |
Congenital Heart Diseases | DRUG: Ulinastatin | 2015-04-01 | Phase IV/Unknown | China | NCT02527811 | |
Patent Ductus Arteriosus | DRUG: ibuprofen/DRUG: paracetamol | 2015-06-01 | Phase IV/Unknown | NCT03265782 | ||
Hypoplastic Left Heart Syndrome/Hypoplastic Right-sided Heart Complex | Drug: Ambrisentan/Other: Placebo | 2015-07-01 | Phase II/Completed | United States | NCT02080637 | |
Congenital Heart Disease | DRUG: Histidine Tryptophan Ketoglutarate Solution/OTHER: Terminal Warm Blood Cardioplegia | 2015-12-01 | Phase II/Unknown | Indonesia | NCT02618824 | |
Ductus Arteriosus, Patent | DRUG: Paracetamol/DRUG: Ibuprofen | 2015-12-01 | Phase II/Completed | Italy | NCT02422966 | |
Heart Defects, Congenital | DRUG: pH Stat | 2016-03-01 | NA/Unknown | United Kingdom | NCT02358382 | |
Analgesia/Congenital Heart Disease/Surgery | DRUG: paracetamol/DRUG: Morphine | 2016-03-09 | NA/Completed | NCT05853263 | ||
Congenital Heart Disease | DRUG: Custodiol Solution/DRUG: Blood cardioplegia | 2016-03-16 | Phase III/Completed | Saudi Arabia | NCT03082716 | |
Bicuspid Aortic Valve | DRUG: Atorvastatin/DRUG: Placebo | 2016-06-01 | Phase III/Completed | Spain | NCT02679261 | |
Patent Ductus Arteriosus | DRUG: Paracetamol drops/OTHER: Placebo | 2016-06-01 | Phase II/Unknown | Israel | NCT02819414 | |
Heart Valve Disease/Heart Septal Defects, Atrial | DRUG: Dexmedetomidine/DRUG: Ketofol | 2016-06-01 | Phase IV/Completed | India | NCT02867930 | |
Single Ventricle Heart Disease | DRUG: Udenafil/DRUG: Placebo | 2016-07-22 | Phase III/Completed | United States/Canada | NCT02741115 | |
Ventricular Septal Defect | DRUG: Salbutamol/DRUG: Norflouran (Placebo Evohaler(R)) | 2016-10-05 | Phase IV/Completed | Denmark | NCT02914652 | |
Coarctation of Aorta | DRUG: Dexamethasone/DEVICE: ultrasound/PROCEDURE: paravertebral block/DRUG: Bupivacaine/OTHER: isotonic saline | 2016-10-30 | Phase I/Completed | Egypt | NCT03074773 | |
Single Ventricle/Fontan | DRUG: Carvedilol/DRUG: Placebo | 2016-11-01 | Phase IV/Completed | United States | NCT02946892 | |
Patent Ductus Arteriosus | DRUG: Ibuprofen/OTHER: Expectative Management/DRUG: Indomethacin | 2016-12-23 | NA/Completed | Belgium/Netherlands | NCT02884219 | |
Patent Ductus Arteriosus | Drug: Acetaminophen/DRUG: Ibuprofen | 2017-01-01 | NA/Completed | United States | NCT03008876 | |
Noonan Syndrome | DRUG: Simvastatin/DRUG: Placebo | 2017-01-25 | Phase III/Completed | France | NCT02713945 | |
Persistent Ductus Arteriosus | DRUG: Ibuprofen in continuous (24 hours) iv infusion and EchoG/DRUG: IV bolus Ibuprofen slow (15 minutes) and EchoG | 2017-02-20 | Phase III/Unknown | Spain | NCT04282941 | |
Circulatory Perfusion Disorder/Congenital Heart Disease/Single-ventricle | DRUG: Vasopressin, Arginine/DRUG: Placebo | 2017-03-06 | Phase II&III/Completed | United States | NCT03088345 | |
Congenital Heart Disease | DRUG: Dexmedetomidine | 2017-05-20 | Phase II/Unknown | Egypt | NCT03425734 | |
Patent Ductus Arteriosus After Premature Birth | DRUG: Paracetamol/DRUG: Ibuprofen | 2017-07-07 | Phase III/Unknown | Spain | NCT04037514 | |
Congenital Heart Disease | DRUG: Macitentan 10 mg/DRUG: Placebo | 2017-08-14 | Phase III/Completed | United States/Australia/China/Denmark/ Germany/France/New Zealand/ United Kingdom | NCT03153137 | |
Congenital Heart Disease in Children/Inflammatory Response | DRUG: Methylprednisolone/DRUG: Isotonic saline | 2017-10-18 | Phase III/Completed | United States | NCT03229538 | |
Heart Defects, Congenital/Transposition of Great Vessels with Ventricular Inversion | DRUG: Tadalafil 20 Mg/DRUG: Placebo 20 Mg | 2017-10-25 | Phase III/Completed | Switzerland | NCT03049540 | |
Congenital Heart Disease/Oral Aversion | PROCEDURE: Endotracheal intubation | 2018-07-01 | United States | NCT05378685 | ||
Congenital Heart Defects | DRUG: Sevoflurane/DRUG: TIVA | 2018-08-20 | Phase IV/Unknown | Brazil | NCT03630796 | |
Ductus Arteriosus, Patent | DRUG: Rectal Solution/DRUG: Intravenous Infusion | 2018-09-01 | Phase II&III/Unknown | Israel | NCT03604796 | |
Patent Ductus Arteriosus | Drug: Paracetamol 10Mg/mL/Drug: 0.45% Sodium Chloride/ Drug: Ibuprofen/ Drug: Indomethacin | 2018-09-03 | Phase I/Recruiting | Finland | NCT03648437 | |
Low Cardiac Output Syndrome/Cardiac Surgical Procedures/Infant | DRUG: Milrinone/DRUG: Normal saline | 2019-02-01 | Phase III/Unknown | China | NCT03823781 | |
Congenital Heart Disease in Children/Neuroprotection | DRUG: Allopurinol/DRUG: Mannitol | 2020-02-14 | Phase III/Recruiting | Netherlands | NCT04217421 | |
Patent Ductus Arteriosus | DRUG: Ibuprofen/DRUG: Paracetamol/OTHER: Expectant Management | 2019-02-15 | NA/Completed | Ukraine | NCT03860428 | |
Congenital Heart Disease/Upper Gastrointestinal Bleeding/Stress Ulcer/Infection | DRUG: Famotidine/DRUG: Placebo | 2019-03-10 | Phase IV/Completed | United States | NCT03667703 | |
Congenital Heart Disease | DRUG: Dexmedetomidine/DRUG: Normal saline | 2020-08-25 | NA/Unknown | Korea | NCT04484922 | |
Myocardial Injury/Cardiac Surgery | DRUG: Cyclosporin/PROCEDURE: remote ischemic preconditioning/DRUG: Placebo | 2020-09-01 | NA/Completed | Indonesia | NCT05691764 | |
Aortic Coarctation | DRUG: Saline Solution/DRUG: Levosimendan/DRUG: Magnesium Sulfate | 2021-02-04 | Phase IV/Completed | Egypt | NCT04330755 | |
Congenital Heart Disease in Children | DRUG: Continuous ketorolac | 2021-03-01 | Phase IV/Recruiting | United States | NCT04040452 | |
Alagille Syndrome | DRUG: Odevixibat/DRUG: Placebo | 2021-03-19 | Phase III/Completed | United States/Canada/France/ Germany/Israel/Italy/Malaysia/ Netherlands/New Zealand/Poland/ Turkey/United Kingdom | NCT04674761 | |
Patent Ductus Arteriosus After Premature Birth/Patent Ductus Arteriosus Conservative Management | Drug: Ibuprofen oral suspension/Drug: Placebo | 2021-04-15 | Phase II/Completed | Egypt | NCT05493540 | |
Patent Ductus Arteriosus | DRUG: Paracetamol injection/DRUG: Ibuprofen injection | 2021-09-03 | Phase II&III/Recruiting | United Kingdom | NCT04986839 | |
Congenital Heart Disease in Children/Cardiopulmonary Bypass | DRUG: Placebo/DRUG: Dexmedetomidine Hcl 100 Mcg/mL Inj/DRUG: Dexmedetomidine Hcl 100 Mcg/mL Inj | 2021-12-16 | Phase II&III/Completed | Indonesia | NCT05300802 | |
Patent Ductus Arteriosus After Premature Birth | DRUG: Ibuprofen | 2022-01-10 | Phase III/Recruiting | United States/Canada | NCT05011149 | |
22q11 Deletion Syndrome | DRUG: NB-001/OTHER: Placebo | 2022-02-10 | Phase II/Completed | United States/Canada | NCT05290493 | |
Congenital Heart Disease/Congenital Heart Defect/Congenital Heart Malformations | DRUG: Nitric Oxide 20 part per million/OTHER: Standard of care cardiopulmonary bypass | 2022-04-25 | Phase II&III/Enrolling by invitation | United States | NCT05101746 | |
Patent Ductus Arteriosus After Premature Birth | DRUG: Standard Dose Ibuprofen/DRUG: High Dose Ibuprofen | 2022-06-01 | Phase IV/Recruiting | Canada | NCT05325177 | |
Eisenmenger Syndrome | DRUG: Pentoxifylline | 2022-06-03 | NA/Recruiting | Brazil | NCT05611268 | |
Ventricular Septal Defect/Atrioventricular Septal Defect/Primum Atrial Septal Defect | DRUG: L-citrulline/DRUG: Plasmalyte A | 2022-06-29 | Phase III/Recruiting | United States | NCT05253209 | |
Congenital Heart Disease in Children/Cardiopulmonary Bypass/Tetralogy of Fallot | DRUG: Dexmedetomidine Hcl 100 Mcg/mL Inj/DRUG: Placebo | 2022-10-10 | Phase II&III/Completed | Indonesia | NCT05579964 | |
Patent Ductus Arteriosus After Premature Birth | Drug: Acetaminophen Injection/DRUG: Ibuprofen 20 Mg/mL oral suspension or Ibuprofen lysine 10 Mg/mL injection solution (Neoprofen)/OTHER: Sodium chloride 0.9% injection | 2022-12-12 | Phase II/Recruiting | Canada | NCT05340582 | |
Tetralogy of Fallot/Double Outlet Right Ventricle | Other: N-thymidine/Other: Urine Collection/Procedure: Echocardiogram/Procedure: Cardiac MRI/Drug: Propranolol Hydrochloride/Drug: Placebo/Procedure: Physical Exam/Other: Specimen Collection | 2022-12-16 | Phase I/Recruiting | United States | NCT04713657 | |
Cardiac; Dysrhythmia, Postoperative/Congenital Heart Surgery | DRUG: Dexmedetomidine/DRUG: Magnesium Sulfate/DRUG: Amiodarone/DRUG: Procainamide | 2023-01-01 | Phase IV/Unknown | NCT04234906 | ||
Heart Defects, Congenital | DRUG: DEX group/OTHER: Control group | 2023-01-05 | Phase IV/Not yet recruiting | NCT05369949 | ||
Congenital Heart Disease/Heart Failure/Heart Failure with Reduced Ejection Fraction | DRUG: Sacubitril 49 Mg / Valsartan 51 Mg [Entresto] BID/DRUG: Empagliflozin 10 Mg OD | 2023-02-06 | Phase II&III/Not yet recruiting | Mexico | NCT05580510 | |
Single Ventricle Heart Disease | DRUG: Udenafil/DRUG: Placebo | 2023-10-30 | Phase III/Recruiting | United States | NCT05918211 | |
Patent Ductus Arteriosus | DRUG: Paracetamol/DRUG: Ibuprofen | 2023-12-01 | Phase II/Not yet recruiting | NCT06152796 | ||
Adult Congenital Heart Disease/Heart Failure | DRUG: Empagliflozin 10 Mg/DRUG: Placebo | 2024-02-01 | Phase IV/Not yet recruiting | United States | NCT06260059 | |
Patent Ductus Arteriosus | DRUG: Paracetamol | 2024-03-01 | Phase I&II/Not yet recruiting | NCT06256211 | ||
Coarctation of Aorta/High Blood Pressure | DRUG: Losartan/DRUG: Amlodipine/DRUG: Placebo | 2024-04-01 | Phase III/Recruiting | United States | NCT06150560 | |
Congenital Heart Disease/Thiamine Deficiency/Patent Ductus Arteriosus/Ventricular Septal Defect/Atrial Septal Defect | DRUG: Thiamine | 2024-05-01 | Phase I/Recruiting | Indonesia | NCT06298344 | |
Device treatment | Congenital Heart Defects | Device: Implantation and testing of CRT | 2007-05-01 | Phase II & III/ Completed | United States/Germany | NCT00450684 |
Congenital Heart Disease | OTHER: Biventricular pacing | 2007-12-01 | NA/Completed | Canada | NCT02806245 | |
Hypoplastic Left Heart Syndrome | DEVICE: Peritoneal dialysis | 2010-09-01 | NA/Completed | Canada | NCT01215240 | |
Congenital Heart Defect/Surgery-Induced Tissue Adhesions/Hemorrhage | DEVICE: CoSeal Surgical Spray Group | 2011-08-01 | Phase II/ Completed | United States | NCT01330433 | |
Secundum Atrial Septal Defects | DEVICE: transcatheter closure of secundum atrial septal defects in patients | 2012-05-21 | NA/Completed | NCT04488120 | ||
Congenital Heart Disease | DEVICE: Biventricular Pacing | 2012-07-01 | NA/Completed | Canada | NCT02644824 | |
Congenital Heart Disease | DEVICE: Use of high flows versus oxygen therapy/DEVICE: oxygen therapy | 2012-08-01 | NA/Unknown | Italy | NCT01633801 | |
Heart Septal Defects, Ventricular/Double Outlet Right Ventricle, Noncommitted VSD/Double Outlet Right Ventricle, Subaortic VSD/Double Outlet Right Ventricle, Subpulmonary VSD/Supracristal Ventricular Septal Defect | DEVICE: TEE-guided perventricular device closure without CBP/PROCEDURE: Surgery repair with CBP | 2012-12-01 | NA/Completed | China | NCT02361008 | |
Congenital Heart Defects | DEVICE: Warfarin Dosing Aid/OTHER: Standard Practice | 2015-08-01 | NA/Unknown | NCT02475863 | ||
Mitral Valve Insufficiency/Heart Septal Defects, Atrial | DEVICE: Figulla Flex Occluder (Occlutech) | 2016-01-01 | NA/Unknown | Germany | NCT03024268 | |
Congenital Heart Defect | DEVICE: electro-acupuncture /DEVICE: sham | 2017-11-15 | NA/Unknown | United States | NCT03297658 | |
Atrial Septal Defect | DEVICE: Guidewire for echo-guided interventions/DEVICE: Cook lunderquist guidewire | 2018-07-07 | NA/Unknown | China | NCT04096924 | |
Ventricular Septal Defect | DEVICE: Fully Absorbable VSD Occlusion System/DEVICE: VSD Occluder | 2019-04-11 | NA/Unknown | China | NCT03941691 | |
Aortic Stenosis/Aortic Stenosis with Bicuspid Valve | DEVICE: TAVR with Venus A plus using supra-annular sizing and THV implantation technique (Hangzhou solution)/DEVICE: TAVR with Venus A plus using annular sizing and THV implantation technique | 2021-04-12 | NA/Recruiting | China | NCT04722796 | |
Atrial Septal Defect | DEVICE: ASD closure with the novel occluder/DEVICE: ASD closure with normal occluder | 2022-04-22 | NA/Unknown | China | NCT05371366 | |
Congenital Heart Disease in Children | DEVICE: Ductal Arterial Stent/PROCEDURE: Systemic-to-Pulmonary Artery Shunt | 2022-06-02 | NA/Recruiting | United States/Canada | NCT05268094 | |
Congenital Heart Disease/Systemic Right Ventricle/Congenitally Corrected Transposition of the Great Arteries/Transposition of Great Vessels/Heart Failure Congenital | DEVICE: CRT ON (biventricular pacing) / CRT OFF (inactive or univentricular pacing)/DEVICE: CRT OFF (inactive or univentricular pacing) / CRT ON (biventricular pacing) | 2022-09-01 | NA/ Active yet recruiting | France | NCT05524324 | |
Ductus Arteriosus, Patent | DEVICE: Percutaneous Patent Ductus Arteriosus Closure / COMBINATION_PRODUCT: Responsive Management Intervention/DIAGNOSTIC_TEST: Echocardiogram, cardiac | 2023-02-21 | NA/Recruiting | United States | NCT05547165 | |
Congenital Heart Disease | DEVICE: method comparison | 2023-03-17 | NA/Recruiting | United States | NCT06078943 | |
Biological treatment | Hypoplastic Left Heart Syndrome/Single Right Ventricle/Single Left Ventricle | GENETIC: Cardiac progenitor cell infusion | 2013-04-01 | Phase II/ Completed | Japan | NCT01829750 |
Congenital Heart Disease | BIOLOGICAL: Fibrinogen Concentrate/BIOLOGICAL: Cryoprecipitate | 2016-03-01 | Phase IV/ Completed | United States | NCT03014700 | |
Turner Syndrome | BIOLOGICAL: PEG-rhGH low dose/BIOLOGICAL: PEG-rhGH high dose/OTHER: Non-treatment control group | 2016-03-01 | Phase II/Unknown | China | NCT03189160 | |
Hypoplastic Left Heart Syndrome/Single Ventricle | GENETIC: Autologous cardiac stem cells | Phase III/Recruiting | Japan | NCT02781922 | ||
Patent Ductus Arteriosus | BIOLOGICAL: Liberal platelet transfusion/BIOLOGICAL: Restrictive platelet transfusion/DRUG: Paracetamol/DRUG: Ibuprofen | 2016-03-01 | Phase III/ Completed | India | NCT03022253 | |
Congenital Heart Disease/Total Cavo-pulmonary Connection | DRUG: Nesiritide/DRUG: Normal saline | 2017-07-05 | NA/Unknown | China | NCT03207295 | |
Hypoplastic Left Heart Syndrome/Atrioventricular Canal | Biological: MPC; rexlemestrocel-L | 2017-11-27 | Phase I/Active not recruiting | United States | NCT03079401 | |
Hypoplastic Left Heart Syndrome | BIOLOGICAL: Longeveron Mesenchymal Stem Cells | 2018-02-21 | Phase I&II/Active not recruiting | United States | NCT03525418 | |
Congenital Heart Disease | BIOLOGICAL: Platelet transfusion/BIOLOGICAL: Fibrinogen concentrate | 2018-03-14 | Phase II/Unknown | Sweden | NCT04807621 | |
Hypoplastic Left Heart Syndrome | BIOLOGICAL: c-kit+ cells | 2019-10-16 | Phase I/Recruiting | United States | NCT03406884 | |
Hypoplastic Left Heart Syndrome | Biological: Lomecel-B medicinal signaling cells | 2021-06-25 | Phase II/Recruiting | United States | NCT04925024 | |
Turner Syndrome | BIOLOGICAL: Lonapegsomatropin/DRUG: Somatropin | 2023-02-15 | Phase II/Active not recruiting | United States | NCT05690386 | |
Behavioral treatment | Heart Defects, Congenital | BEHAVIORAL: Physical Activity/BEHAVIORAL: Education | 2006-08-01 | Phase III/ Completed | Canada | NCT00363363 |
Heart Defects, Congenital | BEHAVIORAL: Motorpedagogic exercise | 2007-02-01 | NA/Unknown | Germany | NCT00436098 | |
Transposition of Great Vessels | BEHAVIORAL: Training | 2009-02-01 | NA/Completed | Germany | NCT00837603 | |
Congenital Heart Defects | BEHAVIORAL: Clinic-based Educational Intervention | 2011-01-01 | NA/Completed | Canada | NCT01286480 | |
Congenital Heart Disease/Post Cardiac Surgery | BEHAVIORAL: Daily Messages, Virtual Home Visits/OTHER: Usual Care | 2012-07-01 | NA/Completed | United States | NCT01941667 | |
Congenital Heart Defects | BEHAVIORAL: Home based interval training | 2012-09-01 | NA/Completed | Sweden | NCT01671566 | |
Congenital Heart Disease | BEHAVIORAL: Educational/BEHAVIORAL: Self-management | 2012-12-01 | NA/Completed | Canada | NCT01723332 | |
Heart Defects, Congenital | BEHAVIORAL: ACHD-CARE Program | 2013-06-01 | NA/Completed | Canada | NCT01881893 | |
Congenital Heart Defect | BEHAVIORAL: home-based exercise training | 2015-01-01 | NA/Completed | Belgium | NCT02240147 | |
Communication/Heart Defects, Congenital/Infant Conditions | BEHAVIORAL: Guided Participation | 2015-02-25 | NA/Completed | United States | NCT04452201 | |
Heart Defects, Congenital | BEHAVIORAL: CHAPTER III Study Intervention | 2015-03-01 | NA/Completed | Canada | NCT02374892 | |
Congenital Heart Disease | BEHAVIORAL: Developmental recommendations/ BEHAVIORAL: Standard care | 2016-01-05 | NA/Completed | United States | NCT02700646 | |
Congenital Heart Defect | BEHAVIORAL: Home based resistance training | 2016-02-01 | NA/Unknown | Sweden | NCT02658266 | |
Congenital Heart Disease | BEHAVIORAL: exercise training | 2016-02-01 | NA/Unknown | Netherlands | NCT02825472 | |
Congenital Heart Disease/Neurodevelopment/Executive Function/Working Memory Training/Infant Open-heart Surgery | BEHAVIORAL: Cogmed Working Memory Training | 2016-06-01 | NA/Completed | United States | NCT02759263 | |
Heart Defects, Congenital | BEHAVIORAL: Pacifier activated music player | 2016-09-15 | NA/Completed | United States | NCT03035552 | |
Congenital Heart Defect/Executive Function/Children/Neurodevelopmental Disorders/Working Memory/Infant Open-Heart Surgery | BEHAVIORAL: Cogmed Working Memory Training | 2017-02-21 | NA/Completed | United States | NCT03023644 | |
Fragile X Syndrome/Williams Syndrome | BEHAVIORAL: Cooperative Parent Mediated Therapy /BEHAVIORAL: As usual | 2017-05-17 | NA/Unknown | Italy | NCT04610424 | |
Cardiovascular Disease Other/Physical Activity | BEHAVIORAL: Physical Activity Lifestyle Intervention/BEHAVIORAL: Physical Activity Monitoring | 2017-11-07 | NA/Completed | United States | NCT03335475 | |
Heart Failure/Congenital Heart Disease | BEHAVIORAL: Respiratory muscle training | 2018-02-15 | NA/Completed | Switzerland | NCT03297918 | |
Congenital Heart Disease/Heart; Surgery, Heart, Functional Disturbance as Result | BEHAVIORAL: Teaching session/BEHAVIORAL: Just TRAC It! /BEHAVIORAL: MyHealth Passport | 2018-04-17 | NA/Completed | Canada | NCT03429335 | |
Heart Defects, Congenital | BEHAVIORAL: REMOTE-CR/OTHER: Control | 2019-02-03 | NA/Recruiting | Sweden | NCT03479957 | |
Congenital Heart Defects | BEHAVIORAL: Psychoeducational intervention | 2019-03-07 | NA/Completed | Portugal | NCT03724006 | |
Cardiovascular Disease Other/Physical Activity | BEHAVIORAL: Physical Activity Lifestyle Intervention/BEHAVIORAL: Physical Activity Monitoring | 2019-03-14 | NA/Completed | United States | NCT04135859 | |
Congenital Heart Disease/Congenital Heart Defect | BEHAVIORAL: Peer Health Coaching | 2020-10-08 | NA/Active not recruiting | United States | NCT04271358 | |
Congenital Heart Disease/Child Development/Early Intervention | BEHAVIORAL: Remotely monitored parent-mediated hybrid home and clinic based multidisciplinary Early Intervention protocols. | 2021-03-16 | NA/Recruiting | Brazil | NCT05907109 | |
Congenital Heart Disease | BEHAVIORAL: Transition care model | 2021-05-03 | NA/Recruiting | Italy | NCT05713591 | |
Congenital Heart Disease/Psychological Intervention/Parenting/Quality of Life/Psychological Disturbance | BEHAVIORAL: problem prevention therapy with congenital heart disease | 2021-05-07 | NA/Unknown | Pakistan | NCT05109806 | |
Down Syndrome | BEHAVIORAL: Combined exercise intervention/BEHAVIORAL: Usual care / Sham intervention | 2021-09-09 | NA/Recruiting | United States | NCT04854122 | |
Congenital Heart Disease/Congenital Heart Disease in Adolescence | BEHAVIORAL: Use of the congenital heart disease app/BEHAVIORAL: Nurse-led intervention | 2022-01-10 | NA/Recruiting | Canada | NCT04463446 | |
Congenital Heart Disease/Congenital Heart Defects | BEHAVIORAL: Cardiac rehabilitation | 2022-02-07 | NA/Enrolling by invitation | Canada | NCT05195788 | |
Congenital Heart Disease | Behavioral: Promoting Resilience in Stress Management/Other: Usual Care | 2023-03-15 | NA/Recruiting | United States | NCT04738474 | |
Heart Defects, Congenital/Breast Feeding | OTHER: Conventional care/BEHAVIORAL: Breastfeeding behavioral intervention for mothers of infants with congenital heart disease | 2023-05-25 | NA/Recruiting | China | NCT05961540 | |
Congenital Heart Disease in Children | BEHAVIORAL: Remote Cardiac Rehabilitation/ BEHAVIORAL: Active Control | 2023-08-31 | NA/Recruiting | United States | NCT06015191 | |
Congenital Heart Disease/Child Development/Neurodevelopmental Disorders/Parents | BEHAVIORAL: Parent-child yoga | 2023-10-01 | NA/Recruiting | Canada | NCT05997680 | |
Cardiology/Infant Development/Development Delay | BEHAVIORAL: NIDCAP Developmental Care | 2023-10-10 | NA/Recruiting | United States | NCT05885113 | |
22Q11 Deletion Syndrome | BEHAVIORAL: Aware Program | 2023-12-18 | NA/Recruiting | United States | NCT05849441 | |
Congenital Heart Disease | BEHAVIORAL: I-InTERACT-North | 2024-02-15 | NA/Recruiting | Canada | NCT06075251 | |
Congenital Heart Disease/Executive Dysfunction/Attention Disorder | Behavioral: Kleuter Extra training program | 2024-03-01 | NA/Not yet recruiting | Netherlands | NCT05885113 | |
Congenital Heart Disease/Executive Dysfunction/Attention Disorder | BEHAVIORAL: Kleuter Extra training program | 2024-03-01 | NA/Not yet recruiting | Netherlands | NCT06267430 | |
Heart Failure Congenital/Single-ventricle | BEHAVIORAL: Cardiac rehabilitation/OTHER: Usual care | 2024-05-05 | NA/Recruiting | United States | NCT06150950 | |
Transition to Adult Care/Congenital Heart Disease | BEHAVIORAL: Get Ready with My Heart Program/BEHAVIORAL: Conventional intervention | 2024-06-01 | NA/Not yet recruiting | China | NCT06418373 | |
Congenital Heart Disease in Adolescence | BEHAVIORAL: Transitional care training with brochures, posters and slide training materials | 2024-06-17 | NA/Not yet recruiting | Turkey | NCT06433401 | |
Other treatments | Adults With Congenitally Malformed Hearts | OTHER: Physician and nurse consultation | 2006-05-01 | NA/Completed | NCT01234753 | |
Congenital Heart Disease | OTHER: transfusion strategy/OTHER: Low Hb transfusion group | 2006-07-01 | Phase II/Completed | United States | NCT00350220 | |
Fontan Procedure/Hypoplastic Left Heart Syndrome/Tricuspid Atresia | DIETARY_SUPPLEMENT: Vitamin C / DIETARY_SUPPLEMENT: Placebo | 2009-06-01 | NA/Completed | United States | NCT00974025 | |
Congenital Heart Disease | DIETARY_SUPPLEMENT: Standard protein delivery/DIETARY_SUPPLEMENT: Intervention 1 (2.2 g/kg/day)/DIETARY_SUPPLEMENT: Intervention 2 (3.0 g/kg/day) | 2009-08-01 | Phase IV/Completed | Canada | NCT01368705 | |
Heart Defects, Congenital | OTHER: NIRS based management/OTHER: Control | 2011-11-01 | NA/Completed | United States | NCT02157597 | |
Impaired Oxygen Delivery/Congenital Heart Disease | OTHER: Red blood cell transfusion/OTHER: Red blood cell transfusion | 2012-01-01 | NA/Completed | United States | NCT01484886 | |
Congenital Heart Disease/Single Ventricle/Univentricular Heart | OTHER: Aerobic Exercise Training/OTHER: Inspiratory Muscle Training/OTHER: No Exercise Training | 2013/1/31 | NA/Completed | Brazil | NCT02283255 | |
Congenital Heart Disease/Heart Defects, Congenital | OTHER: Cardiopulmonary rehabilitation/OTHER: Standard of care | 2013-04-01 | NA/Completed | United States | NCT01822769 | |
Congenital Heart Disease | OTHER: STAGES-Booklet | 2013-06-01 | NA/Completed | Canada | NCT01909583 | |
Tetralogy of Fallot | OTHER: Exercise training | 2015-06-01 | NA/Completed | Slovenia | ||
Congenital Heart Disease | BEHAVIORAL: MyHeartBaby Program | 2015-07-01 | NA/Completed | United States | NCT02895334 | |
Congenital Heart Disease | OTHER: Osteopathy/OTHER: superficial palpatory agreement | 2016-05-01 | NA/Completed | France | NCT02710825 | |
Heart Defects, Congenital | OTHER: Fontan Education Videos | 2016-07-01 | NA/Completed | Canada | NCT02831790 | |
Congenital Heart Disease in Children/Malnutrition, Child | DIETARY_SUPPLEMENT: High-calorie density formula (1 kcal/ml)/DIETARY_SUPPLEMENT: Standard formula (0.67 kcal/ml) | 2018-02-14 | NA/Completed | Indonesia | NCT05945459 | |
Aortic Valve Stenosis/Bicuspid Aortic Valve | DIETARY_SUPPLEMENT: Vitamin K2/OTHER: Placebo | 2016-08-01 | Phase II/Unknown | Netherlands | NCT02917525 | |
Congenital Heart Disease | DIETARY_SUPPLEMENT: Nutritional perioperative prehabilitation program for two weeks/DIETARY_SUPPLEMENT: Nutritional perioperative prehabilitation program for one week | 2017-11-01 | NA/Completed | Egypt | NCT02475759 | |
Patent Ductus Arteriosus After Premature Birth/Hyper Bilirubinemia | OTHER: Group 1: non chest shielding/OTHER: Group 2: chest shielding | 2018-07-01 | NA/Unknown | Turkey | NCT03675425 | |
Heart Defects, Congenital/Adolescent/Young Adult | OTHER: Cardiac rehabilitation | 2018-07-27 | NA/Completed | France | NCT03690518 | |
Infant ALL/Congenital Heart Disease | OTHER: Control/OTHER: Experimental Group (Absorption Group)/OTHER: Experimental Group (Milking Group) | 2018-07-28 | NA/Completed | Turkey | NCT04454294 | |
Congenital Heart Disease/Transition/Pediatric Congenital Heart Disease | BEHAVIORAL: Web-based Educational Intervention | 2018-08-27 | NA/Active not recruiting | United States | NCT03303248 | |
Infant, Premature/Patent Ductus Arteriosus/Infant, Newborn, Diseases/Patent Ductus Arteriosus After Premature Birth | OTHER: Active Treatment/OTHER: Expectant Management | 2018-12-03 | Phase III/Recruiting | United States | NCT03456336 | |
Congenital Heart Disease | OTHER: Sophrology sessions/OTHER: usual care | 2019-07-19 | NA/Completed | France | NCT03999320 | |
Patient Decision Aids/Congenital Heart Disease/Congenital Heart Defect | OTHER: Decision Aid/OTHER: Values Clarification Exercise | 2020-10-01 | NA/Recruiting | United States | NCT04437069 | |
Tetralogy of Fallot/Hypoplastic Left Heart Syndrome/Univentricular Heart/Heart Defects, Congenital | OTHER: Neurally adjusted ventilatory assist first/OTHER: Conventional ventilation first | 2020-10-05 | NA/Recruiting | Canada | NCT04581668 | |
Congenital Heart Defect | OTHER: Individualized Home and Play-Based Physical Activity Plans | 2020-11-1 | NA/Recruiting | Canada | NCT04619745 | |
Mother-Infant Interaction | OTHER: infant massage practice/OTHER: Safe Swaddling/OTHER: Control | 2020-12-01 | NA/Active yet recruiting | Turkey | NCT06158373 | |
Marfan Syndrome | OTHER: Endurance training/OTHER: Muscle building training | 2021-01-04 | NA/Completed | France | NCT04553094 | |
Hypoplastic Left Heart Syndrome/Total Anomalous Pulmonary Venous Return/Truncus Arteriosus/Pulmonary Atresia with Ventricular Septal Defect/Transposition of the Great Arteries/Double Outlet Right Ventricle, Subpulmonary VSD/Tetralogy of Fallot/Double Outlet Right Ventricle with Subaortic Ventricular Septal Defect and Pulmonary Stenosis/Cardiopulmonary Bypass | OTHER: Normoxia (with controlled re-oxygenation)/OTHER: Standard of care ventilation | 2021-01-18 | NA/Not yet recruiting | United States | NCT04452188 | |
Congenital Heart Disease | OTHER: passive range of motion exercise therapy | 2021-02-23 | Phase III/Recruiting | United States | NCT04702373 | |
Congenital Heart Disease | DIETARY_SUPPLEMENT: Infant formula | 2021-04-03 | NA/Completed | Iran | NCT04795076 | |
Congenital Heart Disease in Children | OTHER: early motor intervention | 2021-05-31 | NA/Completed | Switzerland | NCT04666857 | |
Congenital Heart Disease in Children/Stress, Psychological | OTHER: Access to mobile phone application/OTHER: Treatment as usual | 2021-06-01 | NA/Recruiting | Norway | NCT04315610 | |
Congenital Heart Disease in Children/Stress, Psychological | Other: Access to mobile phone application/Other: Treatment as usual | 2021-06-01 | NA/Recruiting | Norway | NCT04315610 | |
Congenital Heart Disease in Children/Post-cardiac Surgery/Malnutrition, Infant | DIETARY_SUPPLEMENT: Energy- Protein Enriched Nutritional Formula | 2021-07-21 | NA/Recruiting | Saudi Arabia | NCT05826769 | |
Mothers/Quality of Life/Self Efficacy/Training | OTHER: Web-Based Education Program | 2022-02-01 | NA/Completed | Turkey | NCT06168344 | |
Congenital Heart Disease | OTHER: Weaning from mechanical ventilation | 2022-04-15 | NA/Completed | Egypt | NCT05344872 | |
Congenital Heart Disease | OTHER: Conventional treatment/OTHER: Limb Range of Motion Exercises + Chest Physical Therapy | 2022-06-20 | NA/Completed | Pakistan | NCT05425173 | |
Breastfeeding/Congenital Heart Disease | OTHER: Breastfeeding | 2022-07-01 | NA/Recruiting | Brazil | NCT06025864 | |
Congenital Heart Disease/Emotional Regulation | OTHER: CHD-specific web-based emotion regulation intervention/OTHER: General web-based emotion regulation intervention | 2022-08-05 | NA/Recruiting | Germany | NCT05862909 | |
Congenital Heart Disease/Mother Child Interaction | OTHER: Creative Music Therapy | 2022-11-22 | NA/Recruiting | Switzerland | NCT05702203 | |
Congenital Heart Defects/Underweight | DIETARY_SUPPLEMENT: pre-surgical nutritional intervention protocol/OTHER: Control | 2023-01-09 | NA/Not yet recruiting | NCT05457712 | ||
Quality of Life/Congenital Heart Disease/Heart; Surgery, Heart, Functional Disturbance as Result | OTHER: pre-operative exercise therapy group/OTHER: control group | 2023-03-01 | NA/Completed | Pakistan | NCT05763238 | |
Congenital Heart Disease | OTHER: blood use for priming cardiopulmonary bypass circuit/OTHER: clear prime for cardiopulmonary bypass | 2023-05-10 | NA/Recruiting | United States | NCT05881564 | |
Congenital Heart Disease | OTHER: Surgical Simulation with 3D Heart Model and Parental Education with “Congenital Heart Disease Parent Education Booklet” and tailored 3D Heart Modeling | 2023-07-01 | NA/Not yet recruiting | Turkey | NCT05852106 | |
Heart Defects, Congenital | OTHER: cardiac rehabilitation program/OTHER: TELEA platform | 2024-01-01 | NA/Not yet recruiting | NCT06185140 | ||
Pulmonary Arterial Hypertension/Heart Defects, Congenital | OTHER: Training | 2024-02-01 | NA/Not yet recruiting | Turkey | NCT06172790 |
