Table 2 Representative cell-penetrating peptides
Class | CPP name | Sequence | Origin | Ref. |
|---|---|---|---|---|
Cationic | TAT (48-60) | GRKKRRQRRRPPQ | HIV-1 TAT | |
TAT (49-57) | RKKRRQRRR | HIV-1 TAT | ||
Penetratin, pAntp (43-58) | RQIKIWFQNRRMKWKK | Antennapedia Drosophila melanogaster | ||
Polyarginines | Rn | Chemically synthesized positively charged sequence | ||
DPV1047 | VKRGLKLRHVRPRVTRMDV | Chemically synthesized positively charged sequence | ||
DP7 | VQWRIRVAVIRK | Parent peptide HH2 | ||
Amphipathic | MPG | GALFLGFLGAAGSTMGA | A fusion sequence of HIV gp41 and NLS of SV40 T-antigen | |
Bac 7 (Bac 1-24) | RRIRPRPPRLPRPRPRPLPFPRPG | Bactenecin family of antimicrobial peptides | ||
pVEC | LLIILRRRIRKQAHAHSK | Vascular endothelial cadherin | ||
ARF (1-22) | MVRRFLVTLRIRRACGPPRVRV | the tumor suppressor protein p14ARF | ||
CADY | GLWRALWRLLRSLWRLLWRA | Derived from PPTG1 peptide, W and charged amino acids | ||
M918 | MVTVLFRRLRIRRACGPPRVRV | the tumor suppressor protein p14ARF | ||
BPrPr (1-28) | MVKSKIGSWILVLFVAMWSDVGLCKKRP | N terminus of unprocessed bovine prion protein | ||
Pep-1 | KETWWETWWTEWSQPKKKRKV | NLS from Simian Virus 40 large T antigen and reverse transcriptase of HIV-1 | ||
MAP | KLALKLALKALKAALKLA | Chemically synthesized amphipathic model peptide | ||
VT5 | DPKGDPKGVTVTVTVTVTGKGDPKPD | Chemically synthesized | ||
Transportan | GWTLNSAGYLLGKINLKALAALAKKIL | Galanin-Lys-mastoparan | ||
p28 | LSTAADMQGVVTDGMASGLDKDYLKPDD | Azurin | ||
Hydrophobic | C105Y | CSIPPEVKFNKPFVYLI | α1-Antitrypsin | |
PFV | PFVYLI | C105Y | ||
Pep-7 | SDLWEMMMVSLACQY | CHL8 peptide phage clone |
