Fig. 6
From: Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Role of Tissue Macrophages in Diseases. In neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, macrophages are implicated in neuronal damage and neurotoxicity, involving the processing of amyloid-beta and alpha-synuclein. In metabolic disorders like obesity, which represents a state of systemic chronic inflammation, macrophages accelerate the development of insulin resistance and affect the efficacy of cell-based immunotherapies through tumor-associated macrophage interactions. Additionally, the diverse functions of macrophages are also evident in the progression of hepatic diseases, including hepatitis, liver cirrhosis, and hepatocellular carcinoma. p-Tau phosphorylated tau, APP amyloid precursor protein, SAPPβ soluble amyloid precursor protein beta, TREM2 triggering receptor expressed on myeloid cells 2, LRRK2 leucine-rich repeat kinase 2, NADPH nicotinamide adenine dinucleotide phosphate (reduced form), NOTCH NOTCH signaling pathway, mTOR1 mechanistic target of rapamycin complex 1, P53 tumor protein p53, CXCL10 C-X-C motif chemokine ligand 10, LGALS3 galectin-3 TNFsf12 tumor necrosis factor superfamily member 12
