Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

Fig. 1

Milestones in the development of BH3-mimetics. a Overview of the anti-apoptotic BCL2 family proteins containing the BH domains and alpha helical structures α1-α9. b General interaction pattern within the BCL2 family, with the anti-apoptotic proteins inhibiting the pore-forming pro-apoptotic proteins BAX and BAK. The BH3-only proteins inhibit the anti-apoptotic BCL2 proteins and may also induce direct activation of BAX and BAK. c Timeline illustrating milestones and achievements in the discovery of BCL2 proteins and the development of BH3-mimetics. a and b Created in BioRender

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