Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

Fig. 3

Genetic alterations in cancer. Analysis of genetic modifications involving BCL2, BCL2L1 and MCL1 using cBioportal541,542,543 was performed. Four main pan-cancer studies using targeted deep sequencing and encompassing 71,060 samples were selected (MSK-IMPACT,544 Cancer Therapy and Clonal Hematopoesis,545 China Pan-Cancer546 and MSK MetTropism547) and analyzed for genetic alterations involving BCL2, BCL2L1 or MCL1 in different cancer types. Thresholds were set for 100 samples / cancer type and a minimal frequency of 0.5%

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