Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: Malaria: past, present, and future

Fig. 8

Endothelial cell activation and P. falciparum erythrocyte membrane protein 1 (PfEMP1)-mediated sequestration of iRBCs. a Mechanistic overview of the process by which activated endothelial cells express receptors that mediate the rolling and eventual sequestration of iRBCs. b PfEMP1 variants interact with distinct endothelial cell receptors. The PfEMP1 variants have been reviewed by Mats Wahlgren.509

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