Fig. 5
From: Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance
Mechanisms of epigenetics impacting on chemotherapy resistance. It depicts the pathways of epigenetic regulation of chemotherapy resistance, which can be summarized into the following four aspects: dysregulation of tumor suppressor gene and oncogene, metabolic reprogramming, unlimited cell proliferation and resistance to cell death, and microenvironment remodeling
