Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance

Fig. 6

Mechanisms of epigenetics impacting on immunotherapy resistance. It illustrates the mechanisms by which epigenetic modifications influence resistance to immunotherapy. Epigenetic processes predominantly modulate the activity of immune cells and the expression of the immune checkpoint proteins, specifically, PD-1 and PD-L1. Particularly, the activity of CD8+ T cells, Tregs, and MDSCs, along with the expression of PD-1, are principal targets for epigenetic regulation in the context of immunotherapy resistance. Tregs regulatory T cells, MDSCs myeloid-derived suppressor cells, NK nature killer cell, DC dendritic cell, M1 M1 macrophages, M2 M2 macrophages

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