Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions

Fig. 3

Crosstalk modes of NR signaling. Various regulatory modes involved in NR signaling influence downstream gene transcription. For example, different types of nuclear receptor signaling can simultaneously regulate the expression of the same gene (Modes 1, 3 and 4) or regulate different genes belonging to the same pathway (Mode 2). Different nuclear receptors may share the same target genes (Mode 5). In addition, crosstalk between two NRs can influence each other’s gene or protein expression (Mode 6)

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