Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions

Fig. 5

Nuclear receptors precisely regulate cell fate and metabolic processes. Nuclear receptors play crucial roles in regulating cell fate by influencing various cellular processes, including proliferation, differentiation, senescence and apoptosis, by acting as transcription factors. Additionally, members of the nuclear receptor family control the synthesis rates of different metabolic enzymes across various tissues, affecting processes such as glucose, lipid and bile acid metabolism, as well as adipocyte differentiation and plasma lipoprotein modulation. By regulating the balance between the storage, utilization and production of these macromolecules, nuclear receptors ensure metabolic flexibility, enabling the organism to adapt to fluctuations in energy availability and demand

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