Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions

Fig. 6

Platelets are good models for investigating the possible nongenomic impacts of nuclear receptors. Because of their anucleate origin, well-characterized mechanisms, and quick reactions, platelets offer a model system for examining any non-genomic impacts of the NRs. Non-genomic roles of NRs include controlling intracellular calcium levels, ion channel function, kinase and phosphatase activity, and second messenger synthesis. It has been discovered that human platelets contain a number of NRs, and that certain NR agonists have anti-platelet actions through a range of mechanisms

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