Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions

Fig. 7

Examples of nuclear receptors involved in regulating metabolic pathways. Cellular metabolic pathways provide the energy and materials essential for cell survival. Nuclear receptors transcriptionally regulate genes that encode nutrient transporters and metabolic enzymes involved in these processes. The pathways include the following: 1. Glycolysis, 2. Pentose phosphate pathway (PPP), 3. Gluconeogenesis, 4. Lactate oxidation, 5. Autophagy, 6. Amino acid catabolism, 7. Redox homeostasis, 8. Mitochondrial biogenesis/dynamics, 9. Oxidative phosphorylation (OXPHOS), 10. Tricarboxylic acid (TCA) cycle, 11. Ketogenesis/ketolysis, 12. Glutaminolysis, 13. Ca2+ homeostasis, 14. Fatty acid oxidation (FAO), 15. Lipolysis

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