Table 2 Summary of ongoing clinical trials of nuclear receptor-targeted drugs

Retinoic acid receptor-α (RARα)

NCT04793919

RECRUITING

Acute Promyelocytic Leukemia

Mylotarg; Arsenic Trioxide; All-trans retinoic acid (ATRA)

PHASE2

NCT04113863

RECRUITING

Breast Neoplasm Female

ATRA; Anastrozole 1 mg

PHASE2

NCT04460963

RECRUITING

Acute Myeloid Leukemia

Adrenomedullin

NA

NCT02688140

ACTIVE_NOT_RECRUITING

Acute Promyelocytic

Leukemia

Arsenic trioxide; Idarubicin;

Cytarabine; Tretinoin; Mitoxantrone; Mercaptopurine; Methotrexate

PHASE3

Peroxisome proliferator-activated receptor-α (PPARα)

NCT05781698

RECRUITING

Inflammatory Bowel Diseases

Mesalamine; Fenofibrate

PHASE2

NCT05753267

RECRUITING

Inflammatory Bowel Diseases

Mesalamine; Fenofibrate

PHASE2;

PHASE3

NCT06125587

ENROLLING_BY_INVITATION

Polycystic Ovary Syndrome

Chiglitazar; Metformin

PHASE2;

PHASE3

NCT06155331

RECRUITING

Breast Cancer Stage 2 and 3

Fenofibrate; Placebo; Doxorubicin; Cyclophosphamide

PHASE4

NCT05542615

RECRUITING

Liver Cirrhosis; Hepatitis C, Chronic; Epigenetic Disorder

Prolonged-Release Pirfenidone

PHASE2

Peroxisome proliferator-activated receptor-γ (PPAR-γ)

NCT02391519

RECRUITING

Pregnancy; IUGR; Preeclampsia

NA

NA

NCT06125587

ENROLLING_BY_INVITATION

Polycystic Ovary Syndrome

Chiglitazar; Metformin

PHASE2;

PHASE3

NCT06010992

RECRUITING

Diabetes Mellitus, Type 2

Nitazoxanide

PHASE2

NCT05542615

RECRUITING

Liver Cirrhosis Hepatitis C, Chronic Epigenetic Disorder

Prolonged-Release Pirfenidone

PHASE2

NCT03468556

NOT_YET_RECRUITING

NASH - Nonalcoholic Steatohepatitis

SNP-610; Placebo Oral Tablet

PHASE2

NCT04114136

RECRUITING

Melanoma;NSCLC; Hepatocellular Carcinoma; Urothelial Cancer; Gastric Adenocarcinoma; HNSCC;Esophageal Adenocarcinoma; Microsatellite Instability-High Solid Malignant Tumor

Nivolumab or Pembrolizumab; Metformin; Rosiglitazone

PHASE2

NCT05767671

RECRUITING

Acute Respiratory Distress Syndrome;Ventilator Associated Pneumonia

OTHER: Non-Bronchoscopic Mini Bronchoalveolar Lavage

NA

NCT06054607

RECRUITING

Aerobic Endurance; Metabolism

DIETARY_SUPPLEMENT: High-amylose maize starch+ acetate/butyrate; Low-amylose maize starch

NA

RAR-related orphan receptor-α (RORα)

NCT04631341

NOT_YET_RECRUITING

Cardiovascular Diseases

DIETARY_SUPPLEMENT: Melatonin

NA

Steroid hormone receptor cnr14 (Sex-1)

NCT06123650

RECRUITING

Stroke, Acute; Dysphagia; Pneumonia

DEVICE: Repetitve transcranial magnetic stimulation; Sham transcranial magnetic stimulation

NA

NCT06123650

RECRUITING

Stroke, Acute; Dysphagia; Pneumonia

DEVICE: Repetitve transcranial magnetic stimulation; Sham transcranial magnetic stimulation

NA

Farnesoid X receptor (FXR)

NCT05718349

RECRUITING

Cholestasis; Icterus; Cholangiocarcinoma; Pancreatic Neoplasms; Liver Metastasis Colon Cancer

OTHER: Biospecimen sampling

NA

NCT03004118

ACTIVE_NOT_RECRUITING

Functional Dyspepsia

DIETARY_SUPPLEMENT: Nutridrink; DEVICE: High resolution manometry probe; DEVICE: perfusion catheter; Placebo Oral Tablet; Ursochol oral tablet; Duodenal fluid aspiration catheter; PROCEDURE: Duodenogastroscopy; Blood sample

PHASE4

NCT04939051

RECRUITING

Barrett Esophagus

PROCEDURE: Biospecimen Collection; Esophageal Biopsy; Esophagogastroduodenoscopy; Liver Ultrasonographic Elastography; BIOLOGICAL: Obeticholic Acid; Placebo Administration; Questionnaire Administration

PHASE2

NCT05740631

RECRUITING

Healthy

Ocaliva; Placebo

NA

NCT05639543

RECRUITING

Alcohol Associated Hepatitis

INT-787; Placebo

PHASE2

Vitamin D receptor (VDR)

NCT05802433

RECRUITING

Vitamin D Deficiency

DIETARY_SUPPLEMENT: Vitamin D3 supplement

NA

NCT05758259

ENROLLING_BY_INVITATION

Acne Vulgaris; Vitamin D

Combination oral and topical vitamin D; Oral placebo and topical cholecalciferol; Oral placebo and basic ingredient placebo topical vitamin D

PHASE4

NCT03513770

RECRUITING

Venous Distension Reflex; Blood Pressure

OTHER: Wrist-to-elbow (W‒E) occlusion; ketorolac tromethamine; saline control

EARLY_PHASE1

NCT02172651

RECRUITING

Colon Cancer (Stage I-III); Stage IV Colon Cancer With Resectable Liver Metastases

Vitamin D3; Placebo

EARLY_PHASE1

NCT03467789

ACTIVE_NOT_RECRUITING

Basal Cell Carcinoma; Basal Cell Nevus Syndrome

Dietary Vitamin D3 pretreatment; RADIATION: Photodynamic therapy; Serum Maintenance Vitamin D3

PHASE1

NCT06209268

NOT_YET_RECRUITING

Sepsis

Paricalcitol injection; Placebo

NA

NCT05043116

RECRUITING

Asthma in Children

DIETARY_SUPPLEMENT: Cholecalciferol D3; Oral placebo suspension

PHASE2

NCT01787409

RECRUITING

Aggressive Non-Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Diffuse Large B-Cell Lymphoma; Enteropathy-Associated T-Cell Lymphoma; B-Cell Lymphoma; Nasal Type Extranodal NK/T-Cell Lymphoma; Mediastinal (Thymic) Large Hepatosplenic T-Cell Lymphoma; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Peripheral T-Cell Lymphoma, Not Otherwise, Specified; Primary Cutaneous Anaplastic Large Cell Lymphoma;Refractory Anaplastic Large Cell Lymphoma; Small Lymphocytic Lymphoma; Subcutaneous Panniculitis-Like T-Cell Lymphoma

DIETARY_SUPPLEMENT: Cholecalciferol

NA

NCT03004118

ACTIVE_NOT_RECRUITING

Functional Dyspepsia

DIETARY_SUPPLEMENT: Nutridrink; perfusion catheter; Placebo Oral Tablet; Ursochol oral tablet; Duodenal fluid aspiration catheter; PROCEDURE: Duodenogastroscopy; Blood sample

PHASE4

NCT04677816

RECRUITING

Triple Negative Breast Cancer; Vitamin D Deficiency; Invasive Breast Cancer

Standard of Care Neoadjuvant Chemotherapy (NAC); DIETARY_SUPPLEMENT: Vitamin D3; Drug Diary

PHASE2

NCT06279910

RECRUITING

SARS-CoV 2 Pneumonia

Calcifediol

NA

NCT03520790

ACTIVE_NOT_RECRUITING

Pancreatic Cancer

Gemcitabine; Nab-paclitaxel; Paricalcitol; Placebo

PHASE1; PHASE2

NCT05981534

RECRUITING

Vitamin D Deficiency; Sarcopenia; Knee Osteoarthritis

Vitamin D; Placebo

NA

NCT05720273

RECRUITING

Chronic Kidney Disease-Mineral and Bone Disorder

Palicalcitol

PHASE4

NCT06289257

NOT_YET_RECRUITING

Endometriosis

DIAGNOSTIC_TEST: Vitamin D level; Vitamin D receptor

NA

NCT06327581

RECRUITING

Alopecia Areata

Lactic Acid; vit D; Triamcinolone Acetonide; Saline

NA

NCT05839938

ENROLLING_BY_INVITATION

Allergic Conjunctivitis

Vitamin D; Placebo

NA

NCT05497596

RECRUITING

Urticaria

Vitamin D; Placebo

NA

NCT05633472

RECRUITING

Postacute COVID-19 Syndromes

Vitamin D; Placebo

NA

NCT05523986

RECRUITING

Atopic Dermatitis

Vitamin D; Placebo

NA

NCT03613116

ACTIVE_NOT_RECRUITING

Vitamin D Deficiency; Cognitive Decline

DIETARY_SUPPLEMENT: Vitamin D3

PHASE2

NCT02876211

RECRUITING

Anemia

Paricalcitol; Epoetin beta; Placebo

PHASE4

Pregnane X receptor (PXR)

NCT03004118

ACTIVE_NOT_RECRUITING

Functional Dyspepsia

DIETARY_SUPPLEMENT: Nutridrink; DEVICE: High resolution manometry probe; DEVICE: perfusion catheter; Placebo Oral Tablet; Ursochol oral tablet; DEVICE: Duodenal fluid aspiration catheter; PROCEDURE: Duodenogastroscopy; Blood sample

PHASE4

Hepatocyte nuclear factor-4-α (HNF4α)

NCT06092112

NOT_YET_RECRUITING

Advanced Hepatocellular Carcinoma

CD-801

EARLY_PHASE1

NCT06418659

NOT_YET_RECRUITING

Advanced Hepatocellular Carcinoma

CD-801

EARLY_PHASE1

Estrogen receptor-α (ERα)

NCT02694809

RECRUITING

Ductal Breast Carcinoma In Situ; Postmenopausal

Conjugated Estrogens/Bazedoxifene; Laboratory Biomarker Analysis; Pharmacological Study; Placebo; Quality-of-Life Assessment; Questionnaire Administration

PHASE2

NCT04174352

RECRUITING

ERα+ Breast Cancer; ESR1 Gene Mutation

Tamoxifen; DIAGNOSTIC_TEST: FES PET/CT

EARLY_PHASE1

Glucocorticoid receptor (GR)

NCT03674814

ACTIVE_NOT_RECRUITING

Prostate Cancer

Enzalutamide; Relacorilant

PHASE1

NCT02788981

ACTIVE_NOT_RECRUITING

Breast Cancer

Mifepristone; Placebo; Nab-Paclitaxel

PHASE2

NCT04452500

RECRUITING

PTSD

CORT108297; Placebo

PHASE2

NCT05726292

RECRUITING

Prostate Cancer; Prostate Adenocarcinoma

Relacorilant; Enzalutamide; Placebo (Sugar Pill); Androgen Deprivation Therapy; Radical Prostatectomy

PHASE2

NCT04601038

RECRUITING

Mild Cognitive Impairment; Alzheimer Disease; Memory Impairment

CORT108297; Placebo

PHASE2

NCT04308590

ACTIVE_NOT_RECRUITING

Hypercortisolism

Relacorilant; Placebo

PHASE3

Mineralocorticoid receptor (MR)

Progesterone receptor (PR)

Androgen receptor (AR)