Table 3 Secondary study outcomes.

From: Traumatic spinal cord injury and its correlation to risk of autoimmune/-inflammatory disease

 

Incidence rate ratios of autoimmune disease associated with traumatic spinal cord injury stratified by region of injury.

     

1: Basic adjustmentA

2: CCI adjustedB

3: Fully adjustedC

Autoimmune disease group

Exposure status

N

PYD

Rate; 1000-1

 

Incidense rate ratio (95% CI)

 

All incident types

c-TSCI

130

29,512

4.4

1.70 (1.43 to 2.02)

1.41 (1.18 to 1.67)

1.22 (1.03 to 1.45)

 

t-TSCI

106

21,192

5.0

1.98 (1.63 to 2.39)

1.74 (1.44 to 2.10)

1.49 (1.23 to 1.80)

 

Non-TSCI

274,314

1.4

2.0

1.00 reference

1.00 reference

1.00 reference

Endocrine & haematologic

..

..

..

..

..

..

..

Gastroenterologic

c-TSCI

20

29,512

0.68

1.15 (0.74 to 1.79)

0.97 (0.62 to 1.50)

0.84 (0.54 to 1.30)

 

t-TSCI

22

21,192

1.0

1.82 (1.20 to 2.76)

1.62 (1.07 to 2.47)

1.40 (0.92 to 2.12)

 

Non-TSCI

65,220

1.4

0.47

1.00 reference

1.00 reference

1.00 reference

DM-1E

c-TSCI

29

27,944

1.0

1.80 (1.25 to 2.59)

1.18 (0.82 to 1.69)

0.97 (0.67 to 1.39)

 

t-TSCI

26

19,721

1.3

2.22 (1.58 to 3.42)

1.75 (1.19 to 2.57)

1.41 (0.96 to 2.07)

 

Non-TSCI

51,846

1.2

0.45

1.00 reference

1.00 reference

1.00 reference

Iridocyclitis

..

..

..

..

..

..

..

MSF

c-TSCI

13

28,767

0.45

3.12 (1.81 to 5.38)

2.87 (1.67 to 4.95)

2.70 (1.56 to 4.65)

 

t-TSCI

14

20,907

0.67

4.51 (2.67 to 7.62)

4.29 (2.54 to 7.25)

3.98 (2.36 to 6.72)

 

Non-TSCI

15,709

1.1

0.15

1.00 reference

1.00 reference

1.00 reference

Dermatologic

c-TSCI

23

29,512

0.78

2.73 (1.81 to 4.11)

2.35 (1.56 to 3.54)

2.00 (1.33 to 3.00)

 

t-TSCI

14

21,192

0.66

2.37 (1.40 to 4.00)

2.14 (1.27 to 3.61)

1.77 (1.05 to 3.00)

 

Non-TSCI

28,164

1.4

0.20

1.00 reference

1.00 reference

1.00 reference

Other neurologic

..

..

..

..

..

..

..

Systemic

c-TSCI

29

29,512

0.98

2.01 (1.39 to 2.89)

1.79 (1.24 to 2.57)

1.57 (1.09 to 2.25)

 

t-TSCI

18

21,192

0.85

1.81 (1.14 to 2.87)

1.66 (1.05 to 2.64)

1.43 (0.90 to 2.26)

 

Non-TSCI

53,838

1.4

0.39

1.00 reference

1.00 reference

1.00 reference

  1. AAdjusted for age, calendar year, and sex.
  2. BAdjusted for age, calendar year, sex, and modified Charlson Comorbidity Index.
  3. CAdjusted for age, calendar year, sex, modified Charlson Comorbidity Index, and hospitalization for (bacterial/viral/other) infections.
  4. DPerson years for non-traumatic spinal cord injury population presented in 108 exponent.
  5. EStudy period 1988 – 2018.
  6. FStudy population included from age of 12 years to let statistical model converge.
  7. TSCI Traumatic spinal cord injury, N Counts, PY Person years, CI Confidence interval, c-TSCI Cervical traumatic spinal cord injury, t-TSCI Thoracic traumatic spinal cord injury.
  8. For specification of autoimmune disease group see Supplementary 2.
  9. For specification of stratification of diagnoses in cervical and thoracic traumatic spinal cord injury see supplementary 1.
Back to article page