Table 2 Characteristics of the patient population switching from Escitalopram to another AD.

From: Antidepressant drug switching in the Swiss population with a focus on Escitalopram and drugs with pharmacogenetic dosing guidelines: a drug utilization study using claims data

 

Total [N, %]

Switched to TCA, [N, %]

Switched to SSRI, [N, %]

Switched to other AD, [N, %]

 

2 638

263, 10.0

420, 15.9

1 955, 74.1

 

nPGx

PGx

nPGx

PGx

nPGx

PGx

nPGx

PGx

Total

1 705, 64.6

933, 35.4

0, 0.0

263, 28.2

93, 5.5

327, 35.0

1 612, 94.5

343, 36.8

Gender

 Male

647, 37.9

306, 32.8

0, 0.0

79, 30.0

24, 25.8

103, 31.5

623, 38.6

124, 36.2

 Female

1 058, 62.1

627, 67.2

0, 0.0

184, 70

69, 74.2

224, 68.5

989, 61.4

219, 63.8

age group (in years)

 0–19

34, 2.0

30, 3.2

0, 0.0

10, 3.8

3, 3.2

13, 4.0

31, 1.9

7, 2.1

 20–39

399, 23.4

253, 27.1

0, 0.0

40, 15.2

36, 38.7

93, 28.5

363, 22.5

12, 35.0

 40–64

652, 38.2

381, 40.8

0, 0.0

115, 43.7

45, 48.4

126, 38.5

606, 37.6

140, 40.8

 65–79

309, 18.1

163, 17.5

0, 0.0

66, 25.1

5, 5.4

53, 16.2

304, 18.9

44, 12.8

 80+

311, 18.3

106, 11.4

0, 0.0

32, 12.2

4, 4.3

42, 12.8

307, 19.1

32, 9.3

Region

 Zurich

360, 21.1

203, 21.8

0, 0.0

60, 22.8

14, 18.3

73, 22.3

343, 21.3

70, 20.4

 Espace Mittelland

393, 23.0

205, 21.9

0, 0.0

60, 22.8

19, 20.5

74, 22.6

373, 23.2

71, 20.7

 Lemanic Region

254, 14.9

180, 19.3

0, 0.0

20, 7.6

32, 34.4

78, 23.9

222, 13.8

82, 23.9

 Northwestern Switzerland

278, 16.3

126, 13.5

0, 0.0

42, 16.0

3, 3.2

34, 10.4

274, 17.0

50, 14.6

 Eastern Switzerland

182, 10.7

97, 10.4

0, 0.0

44, 16.7

4, 4.3

24, 7.3

178, 11.1

29, 8.5

 Ticino

122, 7.2

66, 7.1

0, 0.0

12, 4.6

10, 10.7

32, 9.8

112, 6.9

22, 6.4

 Central Switzerland

105, 6.2

53, 5.7

0, 0.0

25, 9.5

7, 7.5

11, 3.4

98, 6.1

17, 4.9

 No information about region

11, 0.6

3, 0.3

0, 0.0

0, 0.0

1, 1.1

1, 0.3

10, 0.6

2, 0.6

  1. AD antidepressant; N number of persons; % percentage of the corresponding total in the column, PGx pharmacogenetic dosing guidelines available; nPGx pharmacogenetic dosing guidelines not available.