Fig. 1: Volcano plots for the effect of ACEs on maternal DNA methylation.

Top five p-value significant (FDR < 0.05) annotated genes for each ACEs category: none (0 ACEs), low (1-3 ACEs), moderate (4-6 ACEs), and high (>6 ACEs) are labelled. All red and blue dots are significant probes (FDR < 0.05), all black dots are those that did not meet FDR significance (FDR > 0.05). Blue indicates a log-fold change with methylation higher in ACE groups versus the unexposed individuals, and red indicates a log-fold change with methylation lower in exposed versus unexposed individuals.