Table 1 Baseline Characteristics of Analytic Discovery Sample (N = 120).

From: Effect of parental adverse childhood experiences on intergenerational DNA methylation signatures from peripheral blood mononuclear cells and buccal mucosa

 

No ACE

ACE 1–3

ACE 4–6

ACE > 6

P-Valuea

 

41 (34)

55 (46)

19 (16)

5 (4)

 

Maternal Age at Birth

 Age in Years (SD)

29.0 (5.4)

28.9 (6.2)

30.2 (5.6)

29.1 (6.6)

0.664

Smoking Status N%

 Persistent Smokingb

1 (2)

2 (4)

0 (0)

0 (0)

0.612

Pre-Pregnancy BMIc

 kg/m2 Mean(SD)

28.3 (4.9)

27.9 (6.9)

28.9 (8.1)

28.5 (6.3)

0.875

CES-Dd Score

 Depression

9 (22)

11 (20)

5 (26)

2 (40)

0.479

Perceived Stress Scoree

 High Stress

0 (0)

2 (3.6)

0 (0)

0 (0)

0.497

Diabetes Status N%

 Insulin disorder

19 (46)

13 (24)

7 (37)

2 (40)

0.0112

Hypertensive Status N%

 Hypertensive disorder

13 (32)

11 (20)

3 (16)

1 (20)

0.160

Race/Ethnicity N%

    

7.23 × 10−8

 Black,Non-Hispanic

2 (4.8)

12 (22)

0 (0)

0 (0)

 

 Hispanic, Foreign-Born

8 (20)

16 (29)

9 (47)

0 (0)

 

 Hispanic, Non-Foreign

27 (65)

23 (42)

5 (26)

4 (80)

 

 Multiracial

1 (2.4)

0 (0)

2 (10)

0 (0)

 

 White, Non-Hispanic

3 (7.3)

4 (7.3)

3 (16)

1 (20)

 

Maternal Education N%

    

7.88 × 10−4

 Less than High School

14 (34)

12 (22)

2 (10)

3 (60)

 

 High School Degree or some college

22 (54)

34 (62)

10 (52)

1 (20)

 

 Any College Degree

5 (12)

9 (16)

7 (37)

1 (20)

 

Parity Status N%

 First child?

29 (71)

32 (78)

11 (58)

3 (60)

0.305

Gestational Age at Birth

 GA in weeks (SD)

38.8 (1.5)

39.1 (1.4)

39.5 (1.3)

39.5 (0.9)

0.393

  1. aUnadjusted p-values derived via chi-square tests for categorical variables and one-way ANOVAs for continuous variables.
  2. bDefined as individuals who reported smoking at early and late trimester.
  3. cBody Mass Index (BMI) in kg/m2.
  4. dCenter for epidemiologic scale for depression at second trimester visit, cut-off of 16 points used for probable depression.
  5. ePerceived Stress Score at second trimester visit, high stress characterized as a score > 27 points.
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