Table 1 Baseline demographic and clinical characteristics of the non-partial responder group vs. partial responder group at 24 h after the sixth ketamine infusion.

From: Non-improvement predicts subsequent non-response to repeated-dose intravenous ketamine for depression: a re-analysis of a 2-week open-label study in patients with unipolar and bipolar depression

Characteristic

Non-partial responder (N = 26)

Partial responder (N = 91)

Total (N = 117)

Age (years)

33.4 ± 12.3/31 (21)

35.4 ± 11.8/33 (21)

34.9 ± 11.9/33 (20)

Female

15 (57.7%)

45 (49.5%)

60 (51.3%)

Ethnicitya

 Han Chinese

26

88 (97.8%)

114 (98.3%)

 Minority

0

2 (2.2%)

2 (1.7%)

Education (years)a

11.2 ± 3.2/12 (5)

12.6 ± 3.0/13 (3)

12.3 ± 3.1/12 (6)

Body mass index (kg/m2)b

22.0 ± 3.4

22.9 ± 3.6

22.7 ± 3.5

Current smoking

3 (11.5%)

18 (19.8%)

19 (17.9%)

Current drinking

0

4 (4.4%)

4 (3.4%)

Family history

 Affective disorders

9 (34.6%)

23 (25.3%)

32 (27.4%)

 Mental disorders

10 (38.5%)

35 (38.5%)

45 (38.5%)

Unipolar depression

21 (80.8%)

69 (75.8%)

90 (76.9%)

Age at first major depressive episode (years)

24.9 ± 11.0/22 (15)

26.6 ± 11.5/23 (17)

26.2 ± 11.3/23 (16)

Outpatients

25 (96.2%)

78 (86.7%)

103 (88.8%)

Prior or current psychiatric hospitalization

11 (42.3%)

22 (24.2%)

33 (28.2%)

TRD

21 (80.8%)

76 (83.5%)

97 (82.9%)

With suicidality (SSI-part I ≥ 2)

14 (53.8%)

61 (67.0%)

75 (64.1%)

Psychiatric comorbidityc

9 (34.6%)

11 (12.1%)

20 (17.1%)

Baseline MADRS score

31.6 ± 8.3

32.3 ± 7.7

32.2 ± 7.8

Current pharmacotherapies

 Dose of antidepressants (mg/day)

41.2 ± 22.1/40 (40)

33.8 ± 23.5/20 (40)

35.5 ± 23.3/30 (40)

 Antidepressant-free

1 (3.8%)

4 (4.4%)

5 (4.3%)

 1 antidepressant

22 (84.6%)

69 (75.8%)

91 (77.8%)

 2 antidepressants

3 (11.5%)

18 (19.8%)

21 (17.9%)

 Mood stabilizers

6 (23.1%)

28 (30.8%)

34 (29.1%)

 Benzodiazepine receptor agonists

13 (50.0%)

43 (47.3%)

56 (47.9%)

 Antipsychotics

14 (53.8%)

50 (54.9%)

64 (54.7%)

  1. Data are n (%), mean (standard deviation [SD]), or mean (SD)/median (quartile range).
  2. TRD treatment-resistant depression, SSI the Beck Scale for Suicidal Ideation, MADRS Montgomery-Åsberg Depression Rating Scale.
  3. aData missing for one participant in the partial responder group.
  4. bData missing for one participant in the non-partial responder group.
  5. All P-values > 0.05 except that listed below; cThe two groups show a significant difference at the 0.05 significance level for psychiatric comorbidity (χ2 = 7.2414, P = 0.007).
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