Table 2 Diagnostic test statistics evaluating the validity of improvement at 4 h after the first ketamine infusion and 24 h after each of the first five ketamine infusions in predicting partial response at 24 h after the sixth ketamine infusion.

From: Non-improvement predicts subsequent non-response to repeated-dose intravenous ketamine for depression: a re-analysis of a 2-week open-label study in patients with unipolar and bipolar depression

 

Non-partial responder (N = 26)

Partial responder (N = 91)

Sensitivity

Specificity

Positive predictive value

Negative predictive value

Youden index

AUC

4 h post-infusion 1a

  

0.544

0.769

0.891

0.328

0.314

0.657

 Non-Improver

20 (76.9%)

41 (45.6%)

      

 Improver

6 (23.1%)

49 (54.4%)

      

24 h post-infusion 1a

  

0.6

0.885

0.947

0.390

0.485

0.742

 Non-Improver

23 (88.5%)

36 (40%)

      

 Improver

3 (11.5%)

54 (60%)

      

24 h post-infusion 2a

  

0.733

0.846

0.943

0.478

0.579

0.790

 Non-Improver

22 (84.6%)

24 (26.7%)

      

 Improver

4 (15.4%)

66 (73.3%)

      

24 h post-infusion 3

  

0.857

0.615

0.886

0.552

0.473

0.736

 Non-Improver

16 (61.5%)

13 (14.3%)

      

 Improver

10 (38.5%)

78 (85.7%)

      

24 h post-infusion 4

  

0.934

0.50

0.867

0.684

0.434

0.717

 Non-Improver

13 (50%)

6 (6.6%)

      

 Improver

13 (50%)

85 (93.4%)

      

24 h post-infusion 5

  

0.989

0.50

0.874

0.929

0.489

0.745

 Non-Improver

13 (50%)

1 (1.1%)

      

 Improver

13 (50%)

90 (98.9%)

      
  1. AUC area under curve.
  2. aData missing for one participant in the partial responder group.
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