Table 3 Diagnostic test statistics evaluating the validity of improvement at 4 h after the first ketamine infusion and 24 h after the first five ketamine infusions (vs. two or three consecutive non-improvements) in predicting partial response at 24 h after the sixth ketamine infusion.
Non-partial responder (N = 26) | Partial responder (N = 91) | Sensitivity | Specificity | Positive predictive value | Negative predictive value | Youden index | AUC | |
|---|---|---|---|---|---|---|---|---|
Two consecutive non-improvements | ||||||||
4 h & 24 h post-infusion 1a | 0.697 | 0.769 | 0.912 | 0.426 | 0.466 | 0.733 | ||
Non-Improver | 20 (76.9%) | 27 (30.3%) | ||||||
Improver | 6 (23.1%) | 62 (69.7%) | ||||||
24 h post-infusion 1 & 2a | 0.798 | 0.808 | 0.934 | 0.538 | 0.605 | 0.803 | ||
Non-Improver | 21 (80.8%) | 18 (20.2%) | ||||||
Improver | 5 (19.2%) | 71 (79.8%) | ||||||
24 h post-infusion 2 & 3b | 0.889 | 0.577 | 0.879 | 0.6 | 0.466 | 0.733 | ||
Non-Improver | 15 (57.7%) | 10 (11.1%) | ||||||
Improver | 11 (42.3%) | 80 (88.9%) | ||||||
24 h post-infusion 3 & 4 | 0.967 | 0.423 | 0.854 | 0.786 | 0.390 | 0.695 | ||
Non-Improver | 11 (42.3%) | 3 (3.3%) | ||||||
Improver | 15 (57.7%) | 88 (96.7%) | ||||||
24 h post-infusion 4 & 5 | 1 | 0.462 | 0.867 | 1 | 0.462 | 0.731 | ||
Non-Improver | 12 (46.2%) | 0 (0.0%) | ||||||
Improver | 14 (53.8%) | 91 (100%) | ||||||
Three consecutive non-improvements | ||||||||
4 h post-infusion 1 and 24 h post-infusion 1 & 2c | 0.841 | 0.731 | 0.914 | 0.576 | 0.572 | 0.816 | ||
Non-Improver | 19 (73.1%) | 14 (15.9%) | ||||||
Improver | 7 (26.9%) | 74 (84.1%) | ||||||
24 h post-infusion 1 & 2 & 3a | 0.921 | 0.577 | 0.882 | 0.682 | 0.498 | 0.843 | ||
Non-improver | 15 (57.7%) | 7 (7.9%) | ||||||
Improver | 11 (42.3%) | 82 (92.1%) | ||||||
24 h post-infusion 2 & 3 & 4b | 0.978 | 0.423 | 0.854 | 0.846 | 0.401 | 0.853 | ||
Non-improver | 11 (43.2%) | 2 (2.2%) | ||||||
Improver | 15 (56.8%) | 88 (97.8%) | ||||||
24 h post-infusion 3 & 4 & 5 | 1.000 | 0.385 | 0.850 | 1.000 | 0.385 | 0.863 | ||
Non-improver | 10 (38.5%) | 0 (0%) | ||||||
Improver | 16 (61.5%) | 91 (100%) | ||||||
