Fig. 3: Gene set enrichment analysis of DGE associated with probiotics compared to the placebo groups. | Translational Psychiatry

Fig. 3: Gene set enrichment analysis of DGE associated with probiotics compared to the placebo groups.

From: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial

Fig. 3

A Comparison of enrichment profiles of REACTOME pathways between the baseline (BL), post-intervention (week 4; PI), and follow-up (week 8; FU) assessment. Significantly upregulated pathways between PI and BL, in probiotics compared to placebo groups were filtered for display (adjusted p ≤ 0.01 and |NES| > 2). Color of cells indicates the NES. Corresponding BH-adjusted p values are also indicated (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001). B Core enriched DEGs for GSEA enriched REACTOME pathways at post-intervention vs baseline. C Trajectories of norm count of core enriched DEGs throughout the study period associated to the pathway neutrophil degranulation. Norm counts are present as M (SE), axes have been edited according to respective norm count for clearer interpretation.

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