Fig. 4: Association between biological/clinical measures and probiotics-induced DEGs from baseline to post-intervention assessment (week 4). | Translational Psychiatry

Fig. 4: Association between biological/clinical measures and probiotics-induced DEGs from baseline to post-intervention assessment (week 4).

From: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial

Fig. 4

A Effect of group x time x gene expression interaction on the biological/clinical measures assessed by LMM. The color scale represents -log scaled ANOVA p-values. Significant interactions are depicted (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001). B Association between the change of ghrelin and significantly associated genes (*p ≤ 0.05) from baseline to post-intervention for both study group. Only DEGs with a significant association to ghrelin are presented. Associations were assessed as Pearson’s correlation (solid line) and partial correlation (dotted line) controlled for (age, sex, BMI). ELANE: Placebo group (correlation: r = −0.42, p = 0.1; partial correlation: r = −0.69, p = 0.01). Probiotics group (correlation: r = 0.32, p = 0.28; partial correlation: r = 0.7, p = 0.02). TREML1: Placebo group (correlation: r = 0.08, p = 0.75; partial correlation: r = 0.061, p = 0.83). Probiotics group (correlation: r = −0.51, p = 0.07; partial correlation: r = −0.6, p = 0.07).

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