Fig. 5: Co-expressed gene modules identification and their association to the probiotics intervention and changes in biological/clinical measures. | Translational Psychiatry

Fig. 5: Co-expressed gene modules identification and their association to the probiotics intervention and changes in biological/clinical measures.

From: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial

Fig. 5

A Identification of co-expressed gene modules based on a weighted gene co-expression network analysis. Colors are randomly assigned to facilitate module identification. B Percentage of probiotics-induced DEGs in modules. N next to module indicates absolute number of DEGs in modules. C Effect of group × time × ME (“module eigengene”) interaction on the biological/clinical measures assessed by LMM. The color scale represents −log scaled ANOVA p-values. Significant interactions are depicted (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001). D Significantly enriched REACTOME pathways in modules associated to ghrelin. BH-adjusted p values for the enrichment test (*p ≤ 0.05). E Identification of genes with a high Module Membership (correlation to ME) and association to ghrelin (LMM assessed significant group × time × gene expression) in M24 and M33.

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