Table 1 (a) Psychological therapies for suicidal behaviors: dialectical behavior therapy; (b) psychological therapies for suicidal behaviors: cognitive-behavioral therapy and psychodynamic therapy; (c) psychological therapies for suicidal behaviors: family therapy; (d) psychological therapies for suicidal behaviors: brief skills training, motivational interviewing-based intervention, intensive community care service, integrative therapy, combination therapy.

From: Psychological interventions for suicidal behavior in adolescents: a comprehensive systematic review

a

Study

Design

N (IG/IC)

In/Outpatient

Age [mean(sd)]

Sex [female, n (%)]

Type SB

Duration intervention

Outcomes/ assessment

Psychological interventions

Pharmacotherapy (yes/no/AN//NS)

Results

p value

OXFORD study quality

Dialectical behavior therapy

 Hiller and Hughes. [22]

Pre/post

IG = 91

CG = NA

Outpatient

IG = 15.2 (1.5)

IG = 76 (84%)

SA, NSSI, SI

IG: 19 weeks of weekly individual therapy, family sessions as needed, weekly multi-family skills groups, phone contacts, DBT consultation team.

-SA, NSSI: L-SASI

IG: DBT-A

NS

Significantly decrease in frequency of SA and NSSI during cycle 1 and the total duration of treatment.

SA: p = 0.02 at the end of cycle 1.

SA: p = 0.05

NSSI: p = 0.009 post-treatment.

4

 Tabbett-Mock et al. [21]

CCT

IG-1 = 425

IG-2 = 393

CG = 367

Inpatient

IG-1 = 15.6 (1.4)

IG-2 = 15.7 (1.4)

CG = 15.59 (1.54)

IG-1 = 282 (66.4%)

IG-2 = 247 (62.8%)

CG = 236 (62.8%)

SA, NSSI, SI

IG: 8 months of DBT milieu treatment: DBT training, token economy, 9 DBT skill groups weekly, daily therapeutic and leisure groups, intensive psychotherapy.

CG: token economy system, CBT skill groups weekly, activity groups weekly, intensive psychotherapy.

-SA, NSSI: medical record

-SI: observation hours for SI

IG-1: DBT Group 1

IG-2: DBT Group 2

CG: TAU

NS

Significantly fewer SA for IG-1 compared to IG-2 and TAU.

Significantly fewer NSSI for IG-1 compared to TAU and compared to IG-2 at post-treatment.

No differences between groups in observation hours for self-injury.

SA: p = 0.037

NSSI: p < 0.001

Self-injury (observation hours): p = 0.901 post-treatment.

2

 Tabbett-Mock et al. [20]

CCT

IG = 425

CG = 367

Inpatient

IG = 15.6 (1.4)

CG = 15.5 (1.5)

IG = 282 (66.3%)

CG = 236 (62.7%)

SA, NSSI, SI

IG: 8 months of DBT milieu treatment: DBT training, token economy, 9 DBT skill groups weekly, daily therapeutic and leisure groups, intensive psychotherapy.

CG: token economy system, CBT skill groups weekly, activity groups weekly, intensive psychotherapy.

-SA, NSSI: medical record.

-SI: observation hours for SI

IG: DBT

CG: TAU

NS

Significantly fewer SA and NSSI for IG compared to CG.

No differences between groups in SI at post-treatment.

SA: p = 0.01.

NSSI: p < 0.05.

SI: p = 0.11 post-treatment

2

 Santamarina-Pérez et al. [8]

RCT

IG = 18

CG = 17

Outpatient

IG = 15.3 (1.2)

CG = 15.2 (1.5)

IG = 16 (88.9%)

CG = 15 (88.2%)

SA, NSSI, SI

IG:16 weeks of biweekly individual session, weekly of group skills training sessions, weekly consultation team meeting, telephone consultations

CG: 16 weeks of biweekly individual session. GS were added by adolescents and parents separately.

-NSSI, SA: C-SSRS

-SI: SIQ-JR

IG: DBT-A

CG: TAU + GS

Yes

Significantly fewer NSSI for IG compared to CG at post-treatment.

No differences between groups in SA, SI at post-treatment.

NSSI: p = 0.045.

SA: NA.

SI: p = 0.515 post-treatment

2

 Berk et al. [16]

Pre/post

IG = 24

CG = NA

Outpatient

IG = 15.2 (1.3)

IG = 22 (92%)

SA, NSSI, SI

IG: 6 months of weekly individual sessions, weekly family group skills training, telephone counselling, consultation among professional staff

-SA, NSSI: clinical interview

-SI: SIQ-JR

IG: DBT

CG: NA

NS

Significant pre/post-treatment decreases in SA, NSSI, SI.

SA: p = 0.046

NSSI: p = 0.001

SI: p < 0.001

4

 Hancock-Johnson et al. [17]

Pre/post

IG = 22

CG = NA

Inpatient

IG = 15.5 (NS)

IG = 18 (81.8%)

SH

IG: 6 months of weekly individual session, regular group sessions, emergency skills coaching, as needed.

-SH: electronic care records, HoNOSCA

IG: DBT.

NS

Significant pre/post-treatment decreases in total SH, specifically in head-banging.

No differences in other self-injurious behaviors.

SH: p = 0.015

Head-banging: p = 0.028.

4

 Flynn et al. [18]

Pre/post

IG = 84

CG = NA

Outpatient

IG = 15.7 (1.1)

IG = 71 (85%)

SH, SI

IG: pretreatment phase of 4–6 weekly individual sessions plus 16 weeks of treatment of weekly individual therapy, group skills training, phone coaching and team consultation.

-SI: QSI

-SH: clinical file

IG: 16-week DBT-A

NS

Significant improvements on presence and frequency of SH and SI pre/post-treatment and at 16-week F/U.

SH (presence and frequency): p < 0.001; p < 0.001

SI: p < 0.001 post-treatment.

SH (presence and frequency): p = 0.003; p = 0.03)

SI: p < 0.001 at 16-weeks F/U.

4

 Gillespie et al. [19]

Pre/post

IG-1 = 84

IG-2 = 68

CG = NA

Outpatient

IG-1 = 15.7 (1.1)

IG-2 = 15.6 (1.2)

IG-1 = 71 (85%)

IG-2 = 58 (85%)

SH, SI

IG-1: 16 weeks of weekly individual therapy, group skills training, phone coaching, and team consultation.

IG-2: additional 8 weeks of the intervention.

-SI: QSI

-SH: clinical file

IG-1: 16-week DBT-A

IG-2: 24-week DBT-A

NS

Significant improvements on presence and frequency of SH and SI pre/post-treatment in both groups.

Significantly greater decrease in SI for 24-week DBT-A compared to 16-week DBT-A pre/post-treatment.

SH (presence and frequency): p = NS

SI: p < 0.001 at post-treatment.

SI: p = 0.03 post-treatment.

4

 McCauley et al. [15]

RCT

IG = 86

CG = 87

Outpatient

IG = 14.8 (1.4)

CG = 15.0 (1.4)

IG = 82 (95.3%)

CG = 81 (94.1%)

SA, NSSI, SI

IG: 6 months of weekly individual and group sessions; weekly therapist-team consultation.

CG: 6 months of weekly individual and group sessions; weekly therapist-team consultation

-SA, NSSI: SASII,

-SI: SIQ-JR

IG: DBT

CG: IGST

AN

Significantly greater decrease in SA, NSSI, SH, SI for IG compared to CG at post-treatment.

No differences between groups in SA, NSSI, SI at 12-month F/U.

SA: p < 0.05

NSSI: p < 0.05

SH: p < 0.05

SI: p = 0.03 post-treatment.

SA: p > 0.05

NSSI: p > 0.05

SI: p = 0.46 at 12-month F/U.

2

 Mehlum et al. [13, 14]

RCT

IG = 39

CG = 38

Outpatient

IG = 15.9 (1.4)

CG = 15.3 (1.6)

IG = 34 (87.2%)

CG = 34 (89.5%)

SA, NSSI, SI

IG: 19 weeks of weekly individual sessions and multi-family skills training.

CG: 19 weeks of weekly individual sessions.

-SA, NSSI: LPC interview.

-SI: SIQ-Jr

IG: DBT-A

CG: E-TAU

AN

Significantly fewer SH and significantly greater decrease in SI for IG compared to CG at post-treatment.

Significantly fewer SH (SA, NSSI) in IG compared to CG at 1–3-year F/U.

No differences between groups in SI at 1–3-year F/U.

SH: p = 0.021

SI: p = 0.010 post-treatment.

SH: p < 0.05 at 1-year F/U; p < 0.001 at 3-year F/U.

SI: p = 0.110 at 1-year F/U; p = 0.111 at 3-year F/U.

2

b

Cognitive-behavioral therapy (CBT)

 Duarte-Velez et al. [28]

RCT

IG = 24

CG = 22

Outpatient

IG = 15.8 (1.2)

CG = 15.1 (1.4)

IG = 20 (83%)

CG = 37 (80%)

SA, SI

IG: 6 to 14 weeks of weekly sessions, support by collateral case management as needed.

CG: procedures and intensity of treatment was the same as the IG.

-SA: C-SSRS

-SI: SIQ-JR

IG: SCBT-SB CG: TAU

AN

Significantly fewer SA for IG compared to CG from 6 to 12-month F/U.

No differences between groups in SA from BL to 6 or 12-month F/U.

No differences between groups in SI at 3–6–12 month F/U.

SA: Cohen´s h = 0.8 from 6–12-month F/U.

SA: Cohen´s h < 0.1 from BL-6-month F/U; Cohen´s h = 0.4 from BL-12-month F/U.

SI: Cohen´s d = 0.1 at 3-month F/U; Cohen´s d = 0.2 at 6-month F/U; Cohen´s d < 0.05 at 12-month F/U.

2

 Goldston et al. [27]

RCT

IG = 7

CG = 6

Outpatient

IG = 16.43 (NS)

CG = 16.56 (NS)

IG = 3 (42%)

CG = 5 (83%)

SA, SI

IG: 20 weeks, initially weekly with possibility for more frequent sessions, proactive support through phone calls and objective monitoring to enhance treatment effectiveness.

CG: monthly reviews with adolescents/ families to identify treatment needs.

-SA: C-SSRS

-SI: SIQ

IG: CBT-RP + E-TAU

CG: E-TAU

Yes

No differences between groups in SA and SI at post-treatment and 3-month F/U.

NS

2

 Esposito-Smythers et al. [25]

RCT

IG = 74

CG = 73

Outpatient

IG = 15.1 (1.4)

CG = 14.7 (1.5)

IG = 57 (77%)

CG = 55 (75.3%)

SA, NSSI, SI

IG: 12 months of weekly individual and bi-weekly parent sessions (0–6 months), bi-weekly individual sessions and monthly parent sessions (6–9 months), monthly individual and parent sessions (9–12 months).

CG: variable frequency and type of care provided.

-SA: C-SSRS

-NSSI: SITBI

-SI: SIQ-Jr

IG: F-CBT

CG: E-TAU

AN

No differences between groups in SA, NSSI, SI from pretreatment to 6–12–18- month F/U.

SA: p = 0.95

NSSI: p = 0.33

SI: p = 0.49

at 6-month F/U.

SA: p = 0.44

NSSI: p = 0.18

SI: p = 0.95

at 12-month F/U.

SA: p = 0.29

NSSI: p = 0.58

SI: p = 0.38

at 18-month F/U.

2

 Högberg and Hällström. [24]

RCT

IG = 15

CG = 12

Outpatient

IG = 14.2 (1.1)

CG = 15.2 (0.9)

Total sample:

19 (70.3%)

SA, SI

IG: 12 sessions over 8 months.

CG: 20 sessions over 8.5 months.

-SA, SI: C-SSRS

IG: MR-CBT

CG: TAU

AN

No differences between groups in SA or SI at post-treatment.

SA, SI: p = 0.07 post-treatment.

2

 Esposito-Smythers et al. [26]

RCT

IG = 41

CG = 40

Outpatient

IG = 15.4 (1.4)

CG = 15.4 (1.4)

IG = 23 (56%)

CG = 24 (60%)

SH (SA, NSSI) SI

IG: 2 weekends of joining parent-adolescent sessions and individualized booster session post-intervention

CG: NS

-SH (SA, NSSI)

-SI: SITBI 2.0-SF

IG: ASH-P

CG: AO-C

AN

Significantly greater reductions in SH for IG compared to CG at 12-month F/U.

No differences between groups in SH at 6-month F/U.

No differences between groups in SI at 6–12-month F/U.

SH: p ≤ 0.01 at 12-month F/U.

SH: p > 0.05 at 6-month F/U.

SI: p > 0.05 at 6–12-month F/U.

2

 Hetrick et al. [23]

RCT

IG = 26

CG = 24

Secondary school

IG = 14.8 (1.6)

CG = 14.5 (1.3)

IG = 21 (80.7%)

CG = 20 (83.3%)

SA, SI

IG: 8 modules of CBT delivered over 10 weeks.

CG: contact with school wellbeing staff and any outside mental health service provision normally available.

-SA: 2-item questionnaire

-SI: SIQ

IG: Reframe-IT + TAU

CG: TAU

AN

No differences between groups in SA or SI from BL to post-treatment or BL to 22-week F/U.

SA: p > 0.05

SI: p > 0.05 post-treatment.

SA: p > 0.05

SI: p = 0.593

at 22-week F/U.

2

Psychodynamic therapy

Mentalization-based therapy (MBT)

 Jørgensen et al. [33]

RCT

IG = 55

CG = 56

Outpatient

IG = 15.7 (1.1)

CG = 15.9 (1.0)

IG = 55 (100%)

CG = 55 (98%)

SH

IG: 1 year of 3 introductory sessions, 37 weekly group sessions, 5 individual case formulation sessions, and 6 parent sessions.

CG: 12 individual supportive sessions, one per month.

-SH: RTSHI-A

IG: MBT-G

CG: TAU

Yes

No differences between groups in SH from BL to post-treatment and 3-12-month F/U.

SH: p = 0.17 post-treatment

SH: p = 0.75 at 3-month F/U.

SG: p = 0.67 at 12-month F/U.

2

 Beck et al. [32]

RCT

IG = 55

CG = 56

Outpatient

IG = 15.7 (1.1)

CG = 15.9 (1.0)

IG = 55 (100%)

CG = 55 (98%)

SH

IG: 1 year of 3 introductory sessions, 37 weekly group sessions, 5 individual case formulation sessions, and 6 parent sessions.

CG: 12 individual supportive sessions, one per month.

-SH: RTSHI-A

IG: MBT-G

CG: TAU

AN

No differences between groups in SH at post-treatment.

SH: p = 0.61 post-treatment

2

 Griffiths et al. [30]

RCT

IG = 22

CG = 26

Outpatient

IG = 15.4 (1.3)

CG = 15.7 (1.4)

IG = 17 (77.3%)

CG = 21 (80.8%)

SH

IG: 12 weeks of weekly sessions in group format (10 adolescents per group).

CG: variable.

-SH: RTSHI-A

-SH related hospital: electronic records

IG: MBT-Ai +TAU

CG: TAU

NS

No differences between groups in SH from BL to post-treatment and 12–24-month F/U.

SH: p > 0.05 post-treatment and 12–24-weeks F/U.

2

 Bo et al. [34]

Pre/post

IG = 25

CG = NA

Outpatient

IG = 16.4 (0.9)

IG = 25 (100%)

SH

IG: 1 year of 2 individual case formulation sessions, 6 group introductory sessions, 34 group therapy sessions, 7 parent sessions.

-SH: RTSHI-A

IG: MBT-G

NS

Significant pre/post-treatment decreases in SH.

SH: p = 0.005 post-treatment.

4

Psychodynamic family-based therapy

 Diamond et al. [36]

RCT

IG = 66

CG = 63

Outpatient

IG = 14.3 (7.5)

CG = 12.6 (5.7)

IG = 55 (83.3%)

CG = 52 (82.5%)

SA, NSSI, SI

IG: 16 weeks (1 or 2 weekly sessions) of individual adolescent and parent sessions, joint parent-adolescent sessions.

CG: 16 weeks of weekly individual sessions, one joint adolescent-parent session, four parent education sessions.

-SA, NSSI: C-SSRS

-SI: SIQ-JR,

IG: ABFT

CG: NST-FE

NS

No differences between groups in SA over treatment period.

Significantly fewer percentage of NSSI for IG compared to CG.

No differences between groups in in rate of change of SI,

SI remission rate (SIQ-Jr<12), and SI response rate ( ≥ 50% decrease from BL SIQ-Jr) at post-treatment.

SA: p = 0.37

NSSI: p < 0.05

SI (rate of change): p = 0.18.

2

c

Family therapy

Systemic family therapy

 Cottrell et al. [37, 38]

RCT

IG = 415

CG = 417

Child and adolescent mental health

services

IG = 14.3 (1.4)

CG = 14.3 (1.4)

IG = 368 (89%)

CG = 369 (88%)

SA, NSSI, SI

IG: 6–8 sessions over 6 months.

CG: variable

-SA, NSSI: SASII

-SI: BSS

IG: SHIFT

CG: TAU

NS

No differences between groups in the repetition of SA and NSSI at 12–18-36-month F/U.

Significantly greater decrease in SI for

IG as compared to

CG at 12-month F/U.

No differences between groups in SI at 18-month F/U.

SA, NSSI: p = 0.33 at 12–18-month F/U.

SA, NSSI: p = 0.78 at 36-month F/U.

SI: p = 0.024 at 12-month F/U; p = 0.20 at 18-month F/U.

2

Integrated family therapy

 Ayer et al. [41]

Pre/post

IG-1 = 2399

IG-2 = 494

CG = NA

Outpatient

IG-1 = 16.0 (NS)

CG = 15.6 (NS)

IG-1 = 99 (20%)

IG-2 = 624 (26%)

SA, NSS, ISI

IG-1: 10 sessions over firstly 3 months followed by 2–3 sessions of ACC over 4 to 6 months.

IG-2: FBT included MST (4–6 months, average of 40 direct contact hours) or FSN (3 months of 14 individual sessions, 6 parent group sessions, 4 therapeutic home visits, referrals to support groups).

-SA, NSSI, SI: binary indicators.

IG-1: A-CRA

IG-2: FBT

NS

No differences between groups in SA, NSSI or SI from BL to 12-month F/U.

SA: Effect size = 0.14

NSSI: Effect size = −0-06

SI: Effect size = 0.15 from BL to 12-month F/U.

4

 Wijana et al. [40]

Pre/post

IG = 49

CG = NA

Outpatient

IG = 14.6 (1.3)

IG = 42 (85.7%)

SA, SH

IG: 3 months of bi-weekly meetings, more frequently as needed.

-SA, SH: DSHI-9r

IG: ICT

AN

Significant pre/post-treatment decreases in the frequency of SA and SH.

No differences in SA at 6–12-month F/U.

Significant post-treatment to 6–12-month F/U in the frequency of SH.

SA: p < 0.0001

SH: p = 0.001 at post-treatment.

SA: p = 0.001

SH: p = 0.22 at 6–12-month F/U.

4

 Asarnow et al. [39]

RCT

IG = 20

CG = 22

Outpatient

IG = 14.3 (1.8)

CG = 14.8 (1.8)

IG = 18 (90%)

CG = 19 (86.4%)

SA/ SH, NSSI

IG: 12 sessions over 3 months. Adolescent and parent individual sessions plus joint parent/adolescent sessions, CBT,

DBT skills, and homework.

CG: in-clinic parent session and 3 telephone calls ensuring adherence to treatment.

-SA/SH, NSSI: C-SSRS

IG: SAFETY

CG: E-TAU

NS

Significantly longer time to first SA for IG as compared to CG at 3-month F/U.

No differences between groups in

NSSI at 3-month F/U.

SA: p = 0.01 at 3-month F/U.

NSSI: p = 0.524 at 3-month F/U.

2

Brief family-based therapy

 Wharff et al. [42]

RCT

IG = 68

CG = 71

Hospital, emergency department.

IG = 15.4 (1.3)

CG = 15.6 (1.5)

IG = 50 (74%)

CG = 50 (70%)

SB

IG: one emergency crisis intervention (based on CBT), duration 60–90 min.

CG: standard psychiatric evaluation and clinical/discharge recommendations.

-SB: RFL-A

IG: FBCI + TAU CG: TAU

NS

No differences between groups in SB post-treatment and 1-month F/U.

SB: p = 0.24

2

Support-based therapy

 King et al. [43]

RCT

IG = 223

CG = 225

Inpatient

IG = 15.6 (1.2)

CG = 15.6 (1.4)

IG = 159 (71.3%)

CG = 160 (71.1%)

SA, SI

IG: 3 months of psychoeducation for support, weekly contact between supports and adolescents.

CG: 3 months

-SA: DISC-IV,

-SI: SIQ-JR

IG: YST-II + TAU CG: TAU

AN

Significantly greater risk of death for CG compared to IG at 11-14- year F/U.

SA: p < 0.01 at 11–14-year F/U.

2

d

Brief skills training

 Gryglewicz et al. [50]

Pre/post

IG = 460

CG = NA

Outpatient

IG = 14.6 (1.8)

CG = 334 (75.2%)

SA, AA, IA, SI

IG: for 3 months, caring contacts were made within 24–72 h post-discharge, followed by weekly sessions for 1 month and monthly sessions for 2 months.

-SA, AA, IA, SI: C-SSRS.

IG: LINC

NS

Significant reductions in SA and SI over the course of treatment.

SA: p < 0.001

SI: p < 0.001

over treatment

4

 Yen et al. [48]

RCT

IG = 25

CG = 25

Inpatient

IG = 15.9 (1.2)

CG = 15. 5 (1.4)

IG = 21 (84%)

CG = 19 (76%)

SA, AA, IA, NSSI, SI

IG: 3 sessions in the inpatient unit (two individual and one among adolescent and parents), and phone contacts over 6-month post-hospitalization.

CG: enhanced monitoring of suicidality and risk factors.

-SA, AA, IA, NSSI, SI: C-SSRS

IG: CLASP-A

CG: E-TAU

NS

No differences between groups in SA from BL to 6-month F/U.

SA: p = NS.

2

 Rengasamy and Sparks. [49]

Pre/post

IG-1 = 72

IG-2 = 70

CG = NA

Outpatient

IG-1 = 15 (1.6)

IG-2 = 15.1 (1.6)

IG-1 = 48 (67%)

IG-2 = 51 (73%)

SA

IG-1: 6 phone contacts with adolescent and guardian post-discharge.

IG-2: single call intervention.

-SA: C-SSRS.

IG-1: MCI

IG-2: SCI

NS

Significantly lower rates of SA for IG-1 compared to IG-2 at 3-month F/U.

SA: p = 0.037 at 3-month F/U.

4

 Kennard et al. [46]

RCT

IG = 34

CG = 32

Inpatient

IG = 14.9 (1.6)

CG = 15.3 (1.4)

IG = 30 (88.2%)

CG = 29 (90.6%)

SA, NSSI, SI

IG: 3-h ASAP intervention plus BRITE App through daily text messages.

CG: Variable.

-SA, NSSI: C-SSRS

-SI: SIQ-JR

IG: ASAP + TAU

CG: TAU

Yes

No differences between groups for all SITBs at 4–12–24-weeks post-hospitalization.

SA: p = 0.17

NSSI: p = 0.98

SI: p = 0.49

at 4–12–24-weeks post-hospitalization.

2

Motivational interviewing-based intervention

 Czyz et al. [53]

SMART

Phase 1:

IG-1 = 40

IG-2 = 40

Phase 2:

IG-1 = 36

IG-2 = 44

Inpatient/ Outpatient

Phase 1:

IG-1 = 15.1 (1.4)

IG-2 = 15.2 (1.3)

Phase 2:

IG-1 = 15.3 (1.3)

IG-2 = 15.0 (1.4)

Phase 1:

IG-1 = 27 (67.5%)

IG-2 = 27 (67.5%)

Phase 2:

IG-1 = 27 (67.5%)

IG-2 = 27 (67.5%)

SA, IA, AA, SI, NSSI

MI-SP: adolescent individual session (60 min) family session (30 minutes) during hospitalization.

Texts: two daily for 4 weeks.

Booster calls: one call with the adolescent and, separately, one call with the parent.

-SA, IA, AA, SI: C-SSRS.

-NSSI: SITBs Interview.

-SI: daily surveys.

Phase 1:

IG-1: MI-SP + TAU

IG-2: MI-SP + text + TAU

Phase 2:

IG-1: add booster calls

IG-2: no booster calls

NS

Phase 1: Significantly lower intensity of SI for IG-1 compared to IG-2.

No differences between groups in SI severity at 1–3-month F/U.

No differences between groups in SA and SB at 1–3-month F/U.

Phase 2: No differences between groups in SI severity at 1–3-month F/U.

No differences between groups in SA and SB at 1–3-month F/U.

Phase1:

SI (intensity): p = 0.018

SI (severity): p = 0.511; p = 0.714 at 1–3-month F/U.

SA: p = 0.139

SB: p = 0.135

Phase 2:

SI (severity): p = 0.067; p = 0.151 at 1–3-month F/U.

SA: p = 0.654; SB: p = 0.685 at 1–3-month F/U.

2

 Czyz et al. [52]

RCT

IG = 18

CG = 18

Inpatient

Total sample = 15.4 (1.3)

Total Sample = 28 (78.8%)

SA, SI

IG: adolescent individual session (60 minutes), family session (30 min), separate booster phone calls for adolescents and parents.

CG: one or more individual sessions of varying duration.

-SA, SI: C-SSRS

IG: MI-SafeCope + TAU

CG: TAU

NS

Significantly higher self-efficacy to refrain from SA for IG compared to CG at 1–3-month F/U.

Significantly greater reliance on self to cope with SI, and significantly higher likelihood of safety plan uses to manage SI for IG compared to CG at 2-week, 1–3-month F/U.

No differences between groups in SA or SI (frequency and duration) at 1–3-month F/U.

SA (self-efficacy): p = 0.030 at 1–3-month F/U.

SI (coping relying on self): p = 0.042

SI (safety plan use): p = 0.004 at 2-week, 1–3-month F/U.

SA: p = NS.

SI (frequency; duration): p = 0.76; p = 0.575 at 1–3-month F/U.

2

 Grupp-Phelan et al. [51]

RCT

IG = 79

CG = 80

Emergency department.

IG = 15.2 (1.6)

CG = 14.9 (1.5)

IG = 63 (78.8%)

CG = 63 (79.7%)

SA, SI

IG: one brief Motivational Interview session and 1 or 2 F/U case management phone calls.

CG: brief mental health care consultation and referral

-SA: C-SSRS

-SI: SIQ-JR

IG: STAT-ED

CG: E-TAU

NS

No differences between groups in SA at 6-month F/U.

No differences between groups in SI at 2–6-month F/U.

SA: p = 0.62 at 6-month F/U.

SI: p = 0.72 at 2–6-month F/U.

2

Intensive community care service

 Ougrin et al. [54, 55]

RCT

IG = 53

CG = 53

Outpatient.

IG = 16.2 (1.5)

CG = 16.3 (1.7)

IG = 36 (68%)

CG = 33 (62%)

SH

IG: approximately 4 months of intensity of care flexible, with a maximum of daily contacts.

CG: approximately 2 months.

-SH: SHQ

IG: SDS

CG: TAU

NS

Significantly greater reductions in multiples episodes of SH for IG compared to CG at 6-month F/U.

No differences between groups in any or serious SH.

SH (5 > ): p = 0.008 at 6-month F/U.

SH (any/serious): p = 0.560 at 6-month F/U.

2

Integrative therapy.

 English et al. [56]

Pre/post

IG = 21

CG = NA

Child and adolescent mental health services

IG = 15.7 (NS)

IG = 17 (81%)

SH

IG: START consisting of TA followed by one of the following modules: SFBT (4–6 sessions), CBT (8–16 sessions) or MBT-A (16–24 sessions).

-SH: SHQ

IG: START (SFBT + CBT + MBT-A)

Yes

START significantly reduced the number of SH pre/post-treatment.

CBT alone significantly reduced SH.

Insufficient data to prove the efficacy of SFBT or MBT-A alone.

SH: p < 0.02 at post-treatment (START)

SH: p = 0.027 at post-treatment (CBT)

4

Combination therapy.

 Joyce et al. [57]

Trajectory study

Total Sample=84909

Inpatient/outpatient

Total Sample=15.0 (2.6)

Total Sample=49995 (59%)

SA

NS

NS

Group 1: Antidepressant Monotherapy

Grupo 2: Psychotherapy Monotherapy

Group 3: Dual Therapy

Group 4: No treatment

Yes

Psychotherapy monotherapy lowest incidence of SA;

Dual therapy highest incidence of SA

NS

4

  1. (a) SB suicidal behaviors, NSSI non-suicidal self-injury, SA suicide attempt, SH self-harm, SI suicidal ideation. Design: CCT controlled clinical trials, Pre/post pre/post evaluations, RCT randomized-controlled trial. Psychological Interventions: DBT-A dialectical behavior therapy adapted for adolescents, E-TAU enhanced treatment as usual, GS group sessions, IGST individual and group supportive therapy, TAU treatment as usual. Assessment: C-SSRS Columbia suicide severity rating scale, HoNOSCA the health of national outcomes scale for children and adolescents, LPC lifetime parasuicide count, L-SASI lifetime-SA self-injury count, SASII suicide attempt self-injury interview, SIQ-Jr 15-item self-report suicidal ideation questionnaire–junior. General terms: AS as needed, CG control group, IG intervention group, NA not applicable, F/U follow-up, NS not specified.
  2. (b) SB suicidal behaviors, NSSI non-suicidal self-injury, SA suicide attempt, SH self-harm, SI suicidal ideation, SITBs self-injurious thoughts and behaviors. Design: Pre/post pre/post evaluations, RCT randomized-controlled trial. Psychological Interventions: ABFT attachment-based family therapy, AO-C assessment-only control, ASH-P alcohol, self-harm, and HIV prevention, CBT cognitive behavior therapy, CBT-RP cognitive-behavioral therapy-relapse prevention, E-TAU enhanced treatment as usual, F-CBT family-focused cognitive-behavioral treatment, MBT-A Metallization based treatment for adolescents, MBT-G Mentalization-based treatment in groups, MR-CBT mood-regulation focused cognitive-behavioral therapy, NST-FE family-enhanced nondirective supportive therapy, SCBT-SB socio-cognitive-behavioral therapy for suicidal behaviors, TAU treatment as usual. Assessment: BDI-II Beck depression inventory-II, BPFS-C the borderline personality features scale for children, C-SSRS Columbia suicide severity rating scale, RTSHI-A self-harm subscale of the risk-taking and self-harm inventory for adolescents, SIQ-JR self-report suicidal ideation, SITBI self-injurious thoughts and behavior interview, SITBI 2.0-SF self-injurious thoughts and behavior interview 2.0 short form, SMFQ short mood feelings questionnaire. General terms: BL baseline, CG control group, IG intervention group, NA not applicable, F/U follow-up, NS not specified.
  3. (c) SB suicidal behaviors: NSSI non-suicidal self-injury, SA suicide attempt, SH self-harm, SI suicidal ideation, SITBs self-injurious thoughts and behaviors. Design: Pre/post pre/post evaluations, RCT randomized-controlled trial. Psychological Interventions: ACC assertive continuing care, A-CRA adolescent community reinforcement approach, E-TAU enhanced treatment as usual, FBCI family-based crisis intervention, FBT family-based treatment, F-CBT family-focused outpatient cognitive-behavioral treatment, FSN family support network, ICT intensive contextual treatment, MST multisystemic therapy, SAFETY safe alternatives for teens and youths, SHIFT self-harm family intervention: Family Therapy; TAU treatment as usual, YST-II youth-nominated support team intervention for suicidal adolescents-version II. Assessment: BSS Beck scale for suicidal ideation, C-SSRS Columbia suicide severity rating scale, DISC-IV diagnostic interview schedule for children-version IV, DSHI-9r deliberate self-harm inventory, RFL-A reasons for living inventory for adolescents, SASII suicide attempt self-injury interview, SIQ-Jr self-report suicidal ideation questionnaire-junior. General terms: BL baseline, CG control group, IG intervention group, NA not applicable, F/U follow-up, NS not specified.
  4. (d) SB suicidal behaviors: AA aborted attempt, IA interrupted attempt, NSSI non-suicidal self-injury, SA suicide attempt, SH self-harm, SI suicidal ideation, SITBs self-injurious thoughts and behaviors. Design: Pre/post pre/post evaluations, RCT randomized-controlled trial; SMART sequential, multiple assignment randomized trial. Psychological Interventions: ASAP as safe as possible, CBT cognitive behavior therapy, CLASP-A coping long term with active suicide program for adolescents, E-TAU enhanced treatment as usual, LINC linking individuals needing care, MBT-A Metallization based treatment for adolescents, MCI multiple call intervention, MI-SafeCope motivational interview- enhanced safety planning, MI-SP motivational interview-enhanced safety plan, SCI single call intervention, SDS supported discharge service, SFBT solution focused brief therapy, START specialized therapeutic assessment-based recovery-focused treatment, STAT-ED suicidal teens accessing treatment after an emergency department, TAU treatment as usual. Assessment: ASQ ask suicide screening questions, C-SSRS Columbia suicide severity rating scale, SHQ SH questionnaire, SIQ-Jr self-report suicidal ideation questionnaire–junior; TA therapeutic assessment. General terms: BL baseline, CG control group, IG intervention group, NA not applicable, F/U follow-up, NS not specified.
  5. The bold values correspond to the significative values obtained in the cited researches regarding to the outputs (suicidal thoughts and behaviors) evaluated.