Fig. 2: The signalling pathway of ephrin receptors (EphR) is depicted. | Translational Psychiatry

Fig. 2: The signalling pathway of ephrin receptors (EphR) is depicted.

From: Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches

Fig. 2

SRC family of kinases regulate EphR signalling through phosphorylation. Once active, the EphRs then modulate the activity of the Rho family of GTPases. EphRs modulate the switch between inactive (GDP) and active (GTP) confirmations of the Rho family, or EphRs can cause reversion of the GTP state back to GDP. Influencing cell behaviour, shape, and movement is important for cell migration, axon guidance, synaptic plasticity, tissue morphogenesis, and cancer metastasis. Figure made with BioRender.

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