Fig. 4: Targeting EphA4 in a mouse model of disease. | Translational Psychiatry

Fig. 4: Targeting EphA4 in a mouse model of disease.

From: Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches

Fig. 4

The therapeutic potential of upregulating EphA4 in BFLS mouse models can be explored using pharmacological agents following a high throughput screen (A) or genetic approaches to induce EphA4 expression (B). Detailed analysis of BFLS mouse brain and mouse behaviour can be assessed following EphA4 manipulation to establish the benefit of EphA4 targeting in preclinical models (B). Single cell analysis on BFLS mouse brains can further our knowledge on disease pathogenesis (C). Figure made with BioRender.

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