Fig. 2: Transcription factor binding site motifs significantly differentially methylated in newborn guinea pig blood following antenatal betamethasone exposure. | Translational Psychiatry

Fig. 2: Transcription factor binding site motifs significantly differentially methylated in newborn guinea pig blood following antenatal betamethasone exposure.

From: Identification of a DNA methylation signature in whole blood of newborn guinea pigs and human neonates following antenatal betamethasone exposure

Fig. 2

Binding motifs for PLAGL1, TFAP2C, EGR1, ZNF263, and SP1 were identified to be significantly differentially methylated in the newborn guinea pig blood following ACS exposure. Significant motif sequences (E-value ≤ 0.05) that were identified surrounding the DMCs identified in the PND1 guinea pig blood following ACS are indicated in the bottom row. Transcription factor binding sites that significantly aligned (E-value ≤ 10) to the identified motifs are indicated in the top row. Each nucleotide is represented in a different colour, and the size of each letter represents the probability of the nucleotide at the position.

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