Table 3 Transcription factor binding sites (TFBS) that were significantly differentially methylated in the whole blood of guinea pig and human neonates following ACS.
Transcription factor | Guinea pig | Human |
|---|---|---|
PLAGL1 | 454 sites, 80 genes | 104 DMCs, 26 genes |
Cellular response to stimulus | Gene transcription | |
Signal transduction | ||
Response to chemical | ||
Cell communication | ||
TFAP2C | 356 DMCs, 71 genes | 49 DMCs, 17 genes |
Cell differentiation | No gene sets identified | |
Cell proliferation | ||
Transcription regulation | ||
Cell motiliy | ||
EGR1 | 313 sites, 63 genes | 136 DMCs, 26 genes |
Transcription | No gene sets identified | |
Cellular biosynthetic process | ||
Signalling | ||
Response to stimulus | ||
Cell communication | ||
ZNF263 | 213 DMCs, 50 genes | 84 DMCs, 26 genes |
Transcription regulation activity | No gene sets identified | |
Protein kinase binding | ||
Calcium-dependent protein serine/threonine kinase activity | ||
Cell motility | ||
Cell migration | ||
Cellular response to stimulus | ||
SP1 | 84 sites, 55 genes | 82 DMCs, 23 genes |
Regulation of cell population and proliferation | RNA polymerase II-specific DNA-binding transcription factor binding | |
Cell differentiation | Positive regulation of proteolysis | |
Cell migration | Myeloid cell differentiation | |
Cell motility | Membrane-bounded organelle | |
Signal transduction |
