Fig. 4: β subunit protein levels. | Translational Psychiatry

Fig. 4: β subunit protein levels.

From: Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia

Fig. 4

A (Left) Mean optical density (a.u.) of β4 was significantly lower in P84, relative to P28 male and female mice (F = 9.635, DF = 3, p = 0.013), with no significant sex or age-by-sex interactions. Error bars = SEM. ANOVA (α = 0.05). (Right) Representative blot showing β4 bands at ~51–55 kD. B (Left) Mean optical density (a.u.) of β1 was significantly lower in P84, relative to P28 male and female mice (F = 21.499, DF = 3, p = 0.001). There was also a main effect of sex (F = 6.944, DF = 3, p = 0.027) and a significant age-by-sex interaction (F = 6.835, DF = 3, p = 0.028). Main effect of sex was significant at P28 (F = 12.138, DF = 1, p = 0.040) but not P84 (F = 0.016, DF = 1, p = 0.906). Error bars = SEM. ANOVA (α = 0.05). (Right) Representative blot showing β1 bands at ~50–80 kD. C (Left) Neither age nor sex significantly impacted the mean optical density (a.u.) of β3 and there was not a significant sex by age interaction. Error bars = SEM. ANOVA (α = 0.05). (Right) Representative blot showing β3 bands at ~55 kD (molecular weight of the predominant β3 isoform).

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