Fig. 1: Heat map summarising significant associations of biomarkers of inflammation with the CES-D total score (model 3).

*Only results with P < 0.05 (in the total sample or at least one of the subgroups) or pinteraction < 0.05 (CD244, CD6, FGF-5, IFNγ) are shown. β coefficients indicate standardised changes in CES-D scores by per 1-SD increase in biomarkers of inflammation. Regression models were adjusted for age, sex, study, body mass index, HbA1c, diabetes duration, total cholesterol, triglycerides, use of lipid-lowering drugs, non-steroidal anti-inflammatory drugs, antithrombotic medication, antidepressant medication, and number of diabetes-related comorbidities (model 3). T1D, type 1 diabetes; T2D, type 2 diabetes; Total, all people with type 1 or 2 diabetes.