Fig. 2: . Heat maps summarising associations of biomarkers of inflammation with the CES-D total score and its symptom clusters.

a CES-D score. b Cognitive-affective symptoms. c Somatic symptoms. d Anhedoniasymptoms. *P < 0.05 for associations between biomarkers of inflammation and CES-D or symptom clusters. β coefficients indicate standardised changes in CES-D scores or its symptom clusters per 1-SD increase in biomarkers of inflammation. Regression models were adjusted for age, sex, study, body mass index, HbA1c, diabetes duration, total cholesterol, triglycerides, use of lipid-lowering drugs, non-steroidal anti-inflammatory drugs, antithrombotic medication, antidepressant medication, and number of diabetes-related comorbidities (model 3). Abbreviations:T1D, type 1 diabetes; T2D, type 2 diabetes; Total, all people with type 1 or 2 diabetes.