Table 3 HRs (95% CIs) for mortality according to the α- klotho quartiles.

From: Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study

 

Quartiles of α- klotho (pg/ml)

Q1 (<641)

Q2 (641–793)

Q3 (794–985)

Q4 (>985)

P for trend

All-cause mortality

 Number of deaths (%)

153 (31.55)

107 (22.06)

111 (22.89)

114 (23.51)

 

 Model 1, HR (95%CI)

1

0.68 (0.46, 0.99)

0.65 (0.47, 0.92)

0.75 (0.51, 1.10)

0.11

 P-value

 

0.04

0.01

0.10

 

 Model 2, HR (95%CI)

1

0.76 (0.51, 1.14)

0.77 (0.54, 1.10)

0.91 (0.65, 1.27)

0.61

 P-value

 

0.18

0.15

0.57

 

 Model 3, HR (95%CI)

1

0.74 (0.51, 1.09)

0.79 (0.56, 1.13)

0.91 (0.65, 1.27)

0.70

 P-value

 

0.12

0.19

0.58

 

CVD mortality

 Number of deaths (%)

46 (40.71)

24 (21.24)

22 (19.47)

21 (18.58)

 

 Model 1, HR (95%CI)

1

0.52 (0.24, 1.10)

0.52 (0.23, 1.19)

0.49 (0.22, 1.09)

0.13

 P-value

 

0.09

0.12

0.08

 

 Model 2, HR (95%CI)

1

0.61 (0.29, 1.28)

0.60 (0.25, 1.45)

0.59 (0.25, 1.35)

0.27

 P-value

 

0.19

0.26

0.21

 

 Model 3, HR (95%CI)

1

0.55 (0.27, 1.11)

0.73 (0.35, 1.50)

0.69 (0.31, 1.53)

0.52

 P-value

 

0.09

0.39

0.36

 
  1. Model 1: non-adjusted.
  2. Model 2: adjusted for age, gender, and race.
  3. Model 3: adjusted for age, gender, race, BMI, PIR, education, marital status, smoking status, alcohol, hypertension, diabetes, CVD, sleep disorder, self-reported cancer, self-reported liver diseases, CKD, antidepressant drug, year cycle, depressive symptom severity.
  4. PIR poverty income ratio, CVD cardiovascular disease, CKD chronic kidney disease, HR hazard ratio, CI confidence interval.
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