Table 4 Threshold effect analysis of ln-transformed α-klotho on all-cause mortality in patients with depression.

From: Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study

 

Adjusted HR (95%CI), P-value

Total

0.82 (0.57, 1.20) 0.31

Fitting by two-piecewise Cox proportional risk model

Infection point

6.53[ln(pg/ml)]a

ln-transformed α-Klotho <6.53

0.33 (0.19, 0.56) 0.00

ln-transformed α-Klotho ≥6.53

1.41 (0.84, 2.36) 0.20

P for log-likelihood ratio

<0.001

  1. Cox proportional hazards models were used to estimate HR and 95% CI. Adjusted for age, gender, race, BMI, PIR, education, marital status, smoking status, alcohol, hypertension, diabetes, CVD, sleep disorder, self-reported cancer, self-reported liver diseases, CKD, antidepressant drug, year cycle, depressive symptom severity.
  2. HR hazard ratio, CI confidence interval.
  3. a6.53[ln(pg/ml)] is equivalent to 685.40 pg/ml.
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