Fig. 1: Polygenic overlap between schizophrenia (SCZ) and sex hormone (SH) traits.

Venn diagrams depicting the unique and shared variants associated with SCZ and SH traits. The value and circle size reflect the extent of polygenicity for each trait. Conditional Q‑Q plots of nominal versus empirical -log10 transformed P values in the primary phenotype as a function of significance of SNP associations with the secondary phenotype at the level of P < 1.00, P < 0.1, P < 0.01, and P < 0.001. The dashed line is the expected Q‑Q plot under the null hypothesis. SHBG sex hormone-binding globulin. Total T total testosterone. Bioavailable T bioavailable testosterone. * The results are only for males as data for females is not available.