Fig. 2: Systems biology analysis of P301S and 5xFAD models.
From: Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models
A Shifts in the SNO pattern in P301S mice compared to their WT counterparts. The spheres contain the number of proteins S-nitrosylated in the mutant and WT mice or shared between the mutant and WT mice. B Biological processes related to the pathology which were enriched in the P301S brains. C Pathways analysis that might be regulated by the SNO-proteins in P301S brains. D Shifts in the SNO rates in 5xFAD mice compared to their WT counterparts. E Biological processes related to the pathology which were enriched in the 5xFAD brains. F Pathways analysis that might be regulated by the SNO-proteins in 5xFAD brains. G The shared processes related to AD that were enriched in both models.
