Fig. 3: iNOS, nNOS and 3-Nitrotyrosine (3-Ntyr) levels in the cortices of P301S and 5xFAD mice, and their WT counterparts.
From: Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models
A Representative WB for iNOS, nNOS and 3-Ntyr of the cortices of P301S mice and their WT counterparts. B The relative abundance of iNOS normalized to β-actin (a marker of protein loading). WT mice (n = 4), P301S mice (n = 4). C The relative abundance of nNOS normalized to β-actin. WT mice (n = 5), P301S mice (n = 5). D The relative abundance of 3-Ntyr normalized to β-actin. WT mice (n = 5), P301S mice (n = 5). E Representative WB for iNOS, nNOS, and 3-Ntyr prepared from the cortices of 5xFAD mice and their WT counterparts. F The relative abundance of iNOS normalized to β-actin. WT mice (n = 5), 5xFAD mice (n = 5). G The relative abundance of nNOS normalized to β-actin. WT mice (n = 5), P301S mice (n = 5). H The relative abundance of 3-Ntyr normalized to β-actin. WT mice (n = 5), 5xFAD mice (n = 5). An unpaired/independent two-tailed test was used. *p ≤ 0.05, ns non significant.
