Fig. 7: The levels of the mTOR-related proteins in the cortices of P301S and 5xFAD mice, and their WT counterparts.
From: Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models
A Representative WB for p-AKT, AKT, TSC2, p-mTOR, mTOR, p-RPS6, and RPS6 of the cortices of P301S and WT mice. B The relative abundance of p-AKT normalized for AKT and β-actin. WT mice (n = 5), P301S mice (n = 5). C The relative abundance of TSC2 normalized to β-actin. WT mice (n = 5), P301S mice (n = 5). D The relative abundance of p-mTOR normalized to mTOR and β-actin. WT mice (n = 4), P301S mice (n = 4). E The relative abundance of p-RPS6 normalized to RPS6 and β-actin. WT mice (n = 4), P301S mice (n = 4). F Representative WB for p-AKT, AKT, TSC2, p-mTOR, mTOR, p-RPS6, and RPS6 of the cortices of 5xFAD and WT mice. G The relative abundance of p-AKT normalized to AKT and β-actin. WT mice (n = 5), 5xFAD mice (n = 5). H The relative abundance of TSC2 normalized to β-actin. WT mice (n = 5), 5xFAD mice (n = 5). I The relative abundance of p-mTOR normalized to mTOR and β-actin. WT mice (n = 5), 5xFAD mice (n = 5). J The relative abundance of p-RPS6 normalized to RPS6 and β-actin. WT mice (n = 4), 5xFAD mice (n = 4). An unpaired/independent two-tailed test were used, *p ≤ 0.05, **p ≤ 0.01, ns non significant.
