Table 1 The changes in the levels of NO• markers, components of GABAergic and Glutamatergic systems, and critical components of the mTOR signaling pathway as tested using Western blot analysis in the P301S and 5xFAD mouse models at two months of age.
From: Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models
Protein | P301S | 5xFAD | ||
|---|---|---|---|---|
Cortex | Hippocampus | Cortex | Hippocampus | |
3-Ntyr | Increase | Increase | No change | Increase |
iNOS | Increase | Increase | No change | No change |
nNOS | No change | No change | No change | No change |
NR1 | Increase | Decrease | Decrease | Decrease |
GAD1 | No change | No change | No change | No change |
VGAT | No change | Decrease | Decrease | Decrease |
p-AKT | Increase | Increase | No change | No change |
TSC2 | Decrease | Decrease | No change | No change |
p-mTOR | Increase | Increase | No change | No change |
p-RPS6 | Increase | No change | Increase | No change |
