Fig. 1: Diagnostic performance of CSF biomarkers in identifying Aβ-PET confirmed AD from CU controls.

A ROC curves of individual CSF Aβ40, Aβ42, p-tau181, t-tau and Aβ42 combined ratios. B indicate scatterplots of CSF levels across AD and CU controls. The Dashed vertical lines showed the cutoff values that yielded the maximum Youden J Index in the ROC analysis for each biomarker alone or ratios. CSF cerebrospinal fluid, AD Alzheimer’s disease, AUC area under the curve, CU cognitively unimpaired, ROC receiver operating characteristic curve.