Fig. 5: Music prevents neuronal death and promotes neurogenesis. | Translational Psychiatry

Fig. 5: Music prevents neuronal death and promotes neurogenesis.

From: Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model

Fig. 5

A–C Music prevents the loss of MAP2 cells induced by CUMS in the DG and mPFC. D, F Music prevents the reduction of synapse number. E, G Music intervention prevents the reduction of DCX-positive newborn neurons in the DG region. H, I Music prevents the abnormal expression of apoptosis-related factors such as Bax and Bcl-2 in the hippocampus and prefrontal cortex after CUMS. All values are presented as the means ± SEMs. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post-hoc test for multiple comparisons. The normality of the data was assessed using the Shapiro-Wilk test, and F test was used to compare variances between groups. n = 6 per group. *(#,^)P < 0.05; **(##,^^)P < 0.01; ***(###,^^^)P < 0.001. (DAPI: 2 - (4 - Amidinophenyl) – 6 - indolecarbamidine dihydrochloride, DCX: doublecortin, MAP2: microtubule association protein-2, Bax: B-cell lymphoma-2 associated X protein, Bcl-2: B-cell lymphoma-2).

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