Fig. 3: CSDS causes depressive-like behaviors. | Translational Psychiatry

Fig. 3: CSDS causes depressive-like behaviors.

From: Mesoscale brain-wide fluctuation analysis: revealing ketamine’s rapid antidepressant across multiple brain regions

Fig. 3

A Experimental and 10-day chronic social defeat stress (CSDS) timeline. B Schematic of SIT. Two stages: mouse was placed inside an open field with an empty cage and inside an open field with a cage contained a CD1. Gray area referred to social interaction zone. C Representative traces of control and CSDS mice during SIT (‘with CD1’ phase and ‘No CD1’ phase). D Social index of control and CSDS mice (unpaired t-test; CSDS: 0.46 ± 0.08; Control: 1.30 ± 0.06; t = 8.71, ***P < 0.001). E Total movement distance of control and CSDS mice in SIT (unpaired t-test; CSDS: 2150 cm ± 41.68 cm; Control: 2190 cm ± 57.30 cm; t = 0.57, P = 0.5763). F Velocity of control and CSDS mice in SIT (unpaired t-test; CSDS: 3.04 cm/s ± 0.12 cm/s; Control: 3.06 cm/s ± 0.16 cm/s; t = 0.08, P = 0.9399). G Immobility time of control and CSDS mice in TST (unpaired t-test; CSDS: 180.2 s ± 6.36 s; Control: 135.1 s ± 5.47 s; t = 5.37, ***P < 0.001). H Sucrose preference of control and CSDS mice in SPT (unpaired t-test; CSDS: 60.33% ± 1.48%; Control: 77.54% ± 0.88%; t = 10.04, ***P < 0.001). D–H: All data are shown as mean±s.e.m. For Control group: n = 8 mice; For CSDS group: n = 8 mice.

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