Table 1 Participants’ demographics, feedback and regulation strategies.

From: Self-navigating the “Island of Reil”: a systematic review of real-time fMRI neurofeedback training of insula activity

Study

Population

N (F)

Age M (SD)

Target ROIs

Feedback types

Regulation direction

Regulation strategies in regulation (rest)

Berman et al. [84]

Healthy

14 (8)

29.7 (8.2)

rAI

Continuous

Up

Mental imagery (Relaxation)

Böttinger et al. [71]

DBD and healthy

25 (5)

14.57 (1.64)

Insula/amygdala

Continuous

Up

Free (Free)

Buyukturkoglu et al. [72]

OCD

3 (2)

23.33 (3.09)

bAI

Intermittent

Down

Free (Free)

Caria et al. [85]

Healthy

15 (9)

25.13a

rAI

Continuous

Up

Mental imagery (Number counting)

Caria et al. [86]

Healthy

27 (15)

27.51a

lAI

Continuous

Up

Mental imagerya

Emmert et al. [91]

Healthy

28 (14)

27.5 (2.3)

lAIb

Continuous

Down

Free (Free)

Frank et al. [80]

Healthy (obese/lean)

21 (0)

26.24 (0.86)

bAI

Continuous

Up

Mental imagery (Number counting)

Johnston et al. [81]

Healthy

13 (9)

21–52

Insula/amygdala/VLPFC

Continuous

Up

Mental imagerya

Kadosh et al. [83]

Healthy

17 (8)

11.6 (2.5)

rAI

Continuous

Up/Down

Mental imagery (Relaxation)

Kanel et al. [88]

Healthy

20 (13)

24.6 (3.32)

rAI

Continuous

Up

Emotional voice empathizing (Number counting)

Karch et al. [75]

Alcohol addiction and healthy

27a

18–60

Insula/ACC/DLPFC

Continuous

Down

Free (Free)

Karch et al. [76]

Tobacco addiction (abstinence/relapse)

36 (11)

43.83 (12.37)

Insula/ACC/DLPFC

Continuous

Down

Free (Free)

Karch et al. [77]

Alcohol addiction (abstinence/relapse)

48 (7)

45.5 (11.52)

Insula/ACC/DLPFC

Continuous

Down

Free (Free)

Lawrence et al. [87]

Healthy

24 (12)

27.33 (4.71)

rAI

Continuous

Up

Mental imagery/Body awareness (Number counting)

Linden et al. [73]

MDD

16 (3)

48.44 (12.99)

Insula/DLPFC

Continuous

Up

Mental imagery (Relaxation)

Mehler et al. [74]

MDD

32 (21)

47.07 (12.42)

Insula

Continuous

Up

Free (Number counting)

Popovova et al. [90]

Healthy

56 (27)

23.84 (3.3)

rAI

Intermittent

Up

Free (Number counting)

Rana et al. [78]

Nicotine addiction

4a

-

bAI

Intermittent

Down

Freea

Rance et al. [93]

Healthy

10 (4)

29 (6.48)

lPIb

Continuous

Up/Down

Free (Mental arithmetic)

Ruiz et al. [70]

Schizophrenia

9 (5)

26.3 (4.5)

bAI

Continuous

Up

Mental imagery (Relaxation)

Sitaram et al. [79]

Criminal with psychopaths

4a

31.5 (3.5)

lAI

Continuous

Up

Mental imagery (Number counting)

Veit et al. [92]

Healthy

11 (8)

21–28

lAI

Continuous

Up/Down

Mental imagery (Passively watching)

Yao et al. [82]

Healthy

37 (18)

21.97 (1.4)

lAI

Continuous

Up

Mental imagery (Relaxation)

Zhang et al. [89]

Healthy

84 (41)

21.55 (2.06)

lAI

Continuous

Up

Heartbeat interoception (Relaxation)

Zilverstand et al. [47]

Spider phobia

18 (18)

21.2 (1.78)

rAI

Intermittent

Down

Cognitive reappraisal (Relaxation)

  1. ACC anterior cingulate cortex, AI anterior insula, b bilateral, DBD disruptive behavior disorder, DLPFC dorsolateral prefrontal cortex, F female’s number, l left, M mean, MDD major depressive disorder, N numbers of subjects, OCD obsessive-compulsive disorder, PI posterior insula, r right, SD standard deviation, VLPFC ventrolateral prefrontal cortex.
  2. aNo reported results in articles.
  3. bTwo training groups with different target ROIs.