Fig. 6: The effects of alprazolam (0.1 μM for 15 min) last for at least 24 h but not 48 h. | Translational Psychiatry

Fig. 6: The effects of alprazolam (0.1 μM for 15 min) last for at least 24 h but not 48 h.

From: First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis

Fig. 6

A Study design: five cohorts of snails were used in this study: (1) snails exposed to PW for 15 min and tested in PW 18 h later (beige bar); (2) snails exposed to PW for 15 min and tested in FW 18 h later (green bar); (3) snails treated with alprazolam 0.1 μM for 15 min and tested in FW 18 h later (diagonal green bars); (4) snails treated with alprazolam 0.1 μM for 15 min and tested in FW 24 h later (diagonal green bars); and (5) snails treated with alprazolam 0.1 μM for 15 min and tested in FW 48 h later (diagonal green bars). N = 20 each group. B The number of escapes was recorded for 20 min. Alprazolam treatment prevents FW-induced reduction in the number of escapes and this effect lasts for at least 24 h but not 48 h. No effects induced by Alprazolam alone were found. Data are represented as mean ± SEM and analyzed using one-way ANOVA followed by Tukey post hoc tests. ****p < 0.0001; ***p < 0.001; ns = not significant (p > 0.05).

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