Table 1 a Demographic and clinical characteristics of healthy controls and latent profile cognitive groups; b Imaging subjects demographics and characteristics.
From: Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study
a | ||||||
|---|---|---|---|---|---|---|
| Â | Healthy Controls | CCC | Intermediate 1 | Intermediate 2 | Severely Impaired | Â |
|  | N (%) | N (%) | N (%) | N(%) | N(%) | χ2 |
Sex* | ||||||
 Male | 165 (39) | 140 (54) | 388 (50) | 316 (50) | 63 (44) | 22.53 |
 Female | 262 (61) | 117 (46) | 386 (50) | 317 (50) | 80 (56) |  |
Race** | ||||||
 White | 252 (59) | 186 (72) | 443 (57) | 224 (35) | 47 (33) | 182.54 |
 Black | 119 (28) | 40 (16) | 256 (33) | 334 (53) | 71 (50) |  |
 Multi-race, Asian, or Other | 55 (13) | 31 (12) | 75 (10) | 75 (12) | 25 (17) |  |
Ethnicity | ||||||
 Non-Hispanic/Latino/Spanish Origin | 374 (87) | 237 (92) | 687 (88) | 552 (87) | 122 (85) | 8.84 |
 Hispanic/Latino/Spanish Origin | 53 (13) | 20 (8) | 86 (12) | 80 (13) | 21 (15) |  |
| Â | M (SD) | M (SD) | M (SD) | M (SD) | M (SD) | F |
Age (Years)* | 36.15 (12.61) | 34.27 (12.71) | 37.43 (12.20) | 38.93 (11.61) | 36.46 (11.38) | 9.366 |
Age of Onset (Years) | NA | 19.68 (8.73) | 19.53 (8.42) | 19.68 (8.73) | 17.97 (8.29) | 1.341 |
Subject Years of Education** | 15.06 (2.29) | 14.95 (2.34) | 13.74 (2.23) | 12.45 (2.10) | 11.80 (2.02) | 136.34 |
Estimated Premorbid Ability** | 101.77 (13.13) | 109.84 (12.92) | 98.91 (13.22) | 88.06 (12.05) | 83.32 (12.51) | 188.81 |
Number of Hospitalizations* | NA | 4.94 (5.84) | 6.22 (8.11) | 6.83 (8.59) | 7.91 (10.48) | 3.48 |
Social Functioning Scale Total** | 146.94 (26.14) | 135.01 (23.65) | 126.26 (24.46) | 119.79 (24.05) | 103.63 (25.17) | 68.68 |
YMRS Total | NA | 7.47 (7.61) | 7.83(7.07) | 8.13 (7.44) | 8.05 (7.07) | 0.468 |
MADRS Total | NA | 10.28 (9.88) | 11.53 (9.77) | 10.89 (9.69) | 9.38 (9.49) | 2.352 |
PANSS Positive Total** | NA | 14.12 (6.14) | 15.37 (6.07) | 17.10 (6.18) | 17.23 (5.60) | 18.29 |
PANSS Negative Total** | NA | 12.29 (5.44) | 14.05 (5.77) | 16.24 (6.31) | 17.81 (6.49) | 40.005 |
PANSS General Total* | NA | 28.56 (9.42) | 30.58 (9.10) | 32.54 (9.71) | 32.76 (9.59) | 12.453 |
PANSS Total** | NA | 54.97 (18.80) | 60 (18.26) | 65.88 (19.27) | 67.80 (18.90) | 26.404 |
b | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Descriptives (Mean/SD) | Â | Cognition Based Subtyping [Mean(SD)] | Significance | Biotypes [Mean(SD)] | Significance | DSM [Mean(SD)] | Significance | ||||||||||
Controls | Intact | Intermediate 1 | Intermediate 2 | Severe | F score | p value | Biotype1 | Biotype 2 | Biotype 3 | F score | p value | Psychotic Bipolar | Schizoaffective | Schizophrenia | F score | p value | |
|  | N = 427 | N = 104 | N = 332 | N = 228 | N = 49 |  |  | N = 235 | N = 211 | N = 267 |  |  | N = 206 | N = 225 | N = 286 |  |  |
Age (Years) | 36.15 (12.61) | 33.04 (12.19) | 36.83 (12.04) | 37.22 (11.26) | 35.92 (10.50) | 2.42 | 0.05 | 36.82 (11.84) | 38.42 (11.12) | 34.25 (11.93) | 4.98 | NS | 34.94 (12.06) | 37.23 (11.69) | 36.66 (11.58) | 1.42 | NS |
Age of Onset (Years) | NA | 17.37 (6.97) | 18.33 (8.05) | 17.48 (7.38) | 17.50 (7.36) | 0.77 | NS | 17.87 (7.52) | 18.46 (7.92) | 17.39 (7.52) | 1.13 | NS | 16.51 (7.40) | 17.58 (8.39) | 19.06 (7.01) | 6.83 | 0.001 |
Age of Hospitalization (Years) | NA | 24.04 (8.04) | 23.95 (8.56) | 22.77 (8.50) | 22.59 (6.62) | 1.12 | NS | 23.67 (8.68) | 24.02 (8.27) | 22.86 (8.10) | 1.1 | NS | 23.25 (9.13) | 23.73 (8.81) | 23.44 (7.44) | 1.55 | NS |
Number of Hospitalizations | NA | 3.42 (4.49) | 5.63 (6.69) | 6.56 (7.62) | 5.50 (4.58) | 4.5 | 0.004 | 6.09 (7.59) | 6.70 (7.40) | 4.23 (4.63) | 7.71 | <0.001 | 5.08 (7.31) | 6.68 (7.74) | 5.17 (5.18) | 3.47 | 0.03 |
Social Functioning (Occupation/Employment) Total | 6.90 (3.50) | 6.70 (3.35) | 6.48 (3.43) | 6.12 (3.70) | 5.38 (3.56) | 3.23 | 0.01 | 6.54 (3.55) | 5.90 (3.63) | 6.48 (3.39) | 3.77 | 0.01 | 6.44 (3.38) | 6.39 (3.63) | 6.18 (3.54) | 0.05 | 0.01 |
Social Functioning Scale Total | 138.22 (26.14) | 139.55 (26.26) | 135.59 (24.83) | 134.69 (25.52) | 126.61 (21.73) | 2.75 | 0.03 | 134.95 (24.65) | 133.57 (26.05) | 136.97 (24.90) | 1.67 | NS | 137.84 (23.14) | 134.71 (25.93) | 133.95 (25.85) | 1.88 | NS |
YMRS Total | NA | 7.52 (7.11) | 6.96 (6.66) | 7.26 (6.74) | 6.83 (5.92) | 0.24 | NS | 7.03 (6.48) | 7.59 (6.72) | 6.86 (6.88) | 0.71 | NS | 5.65 (6.48) | 8.57 (6.80) | 7.08 (6.55) | 10.19 | <0.001 |
MADRS Total | NA | 9.62 (9.34) | 11.58 (9.28) | 9.94 (8.73) | 10.20 (11.04) | 1.98 | NS | 10.67 (9.89) | 10.46 (8.68) | 10.85 (9.18) | 0.1 | NS | 10.39 (8.89) | 13.18 (10.17) | 8.86 (8.30) | 13.8 | <0.001 |
PANSS Positive Total | NA | 14.13 (5.88) | 15.22 (5.84) | 17.10 (5.88) | 17.28 (6.30) | 8.3 | <0.001 | 15.98 (5.96) | 17.51 (6.00) | 14.31 (5.62) | 17.29 | <0.001 | 12.29 (4.46) | 17.49 (5.97) | 17.01 (5.91) | 56.7 | <0.001 |
PANSS Negative Total | NA | 12.17 (5.07) | 14.35 (5.63) | 16.30 (5.70) | 17.98 (6.38) | 18.22 | <0.001 | 15.18 (6.03) | 15.75 (5.71) | 13.97 (5.66) | 5.75 | 0.003 | 11.75 (3.92) | 15.51 (5.76) | 16.71 (6.16) | 49.56 | <0.001 |
PANSS General Total | NA | 27.87 (8.48) | 30.75 (8.77) | 31.92 (8.87) | 34.17 (10.67) | 7.03 | <0.001 | 30.63 (9.39) | 32.27 (8.83) | 30.16 (8.74) | 3.34 | 0.04 | 27.89 (7.88) | 33.05 (9.20) | 31.47 (9.08) | 18.72 | <0.001 |
Framewise Displacement (mm) | 0.18 (0.09) | 0.19 (0.1) | 0.22 (0.12) | 0.22 (0.12) | 0.26 (0.14) | 11.84 | <0.001 | 0.21 (0.1) | 0.24 (0.13) | 0.21 (0.1) | 17.33 | <0.001 | 0.21 (0.1) | 0.23 (0.12) | 0.22 (0.12) | 12.9 | <0.001 |
Descriptives (Count) | Controls | Intact | Inter 1 | Inter 2 | Severe | Chi-Square | p value | Biotype1 | Biotype 2 | Biotype 3 | Chi-Square | p value | Psychotic Bipolar | Schizoaffective | Schizophrenia | Chi-Square | p value |
Male (N) | 165 | 62 | 168 | 116 | 25 | 21.48 | <0.001 | 126 | 104 | 141 | 19.83 | <0.001 | 74 | 108 | 189 | 64.04 | <0.001 |
Female (N) | 262 | 42 | 166 | 114 | 24 | Â | Â | 109 | 111 | 126 | Â | Â | 132 | 117 | 97 | Â | Â |
