Table 2 Heatmap of post-hoc differences in (a) latent cognitive, (b) Biotypes and (c) DSM derived subgroups of psychosis with respect to controls.

From: Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study

a

Network Domain

Node Label

Omnibus p-value (FDR adjusted)

CCC

Intermediate 1

Intermediate 2

Severe

Auditory

L STG

0.001

0.31

0.34

0.37

0.06

Auditory

R STG

0.001

0.23

0.32

0.50

0.16

BG

R Thalamus-Caudate

0.007

0.15

0.09

0.03

−0.54

BG

L Thalamus-Caudate

0.012

0.11

0.08

−0.03

−0.44

DMN

R IPS-Angular Gyrus

0.009

−0.14

−0.21

0.09

−0.12

DMN

L/R Thalamus

0.010

0.18

0.19

0.21

−0.18

DMN

L Mid FG

0.009

−0.09

−0.25

−0.13

0.15

DMN

R Sup/Mid FG

0.012

−0.03

−0.24

−0.06

0.05

ECN

R IPG-IPS

0.007

−0.26

−0.07

0.19

0.11

ECN

R Caudate

0.005

0.01

−0.13

−0.14

−0.67

Salience

L Ant Insula

0.008

0.04

0.09

0.33

0.09

Salience

R Ant Insula

0.003

0.00

0.20

0.42

0.29

Salience

R Thalamus-Insula

0.004

0.19

0.31

0.18

−0.17

Salience

R Posterior Ins

0.011

−0.04

0.11

0.27

0.01

Salience

L IPL

0.006

0.04

−0.09

0.28

−0.09

Salience

R IPL

0.006

0.01

−0.01

0.32

0.05

Sensorimotor

L Pre-postcentral Gyrus

0.003

0.35

0.28

0.24

0.50

Sensorimotor

R Pre-postcentral Gyrus

0.002

0.26

0.29

0.37

0.52

Visual

L Mid-Sup Occipital Gyrus

0.008

0.22

0.28

0.07

0.26

Visual

R Mid-Sup Occipital Gyrus

0.011

0.15

0.27

0.08

0.18

Visual

Calcarine Sulcus

0.004

0.29

0.27

0.00

0.32

Visual

R MTG

0.002

0.13

0.23

0.40

0.52

b

Network Domain

Label

Omnibus p-value (FDR adjusted)

BioType 1

BioType 2

BioType 3

Auditory

L STG

<0.001

0.29

0.31

0.36

Auditory

R STG

<0.001

0.37

0.37

0.32

DMN

L IPS-Ang Gyrus

0.007

0.00

−0.13

−0.22

DMN

L MOG

0.001

0.12

0.13

−0.17

DMN

R Ang/Mid OG

0.002

0.13

0.17

−0.14

ECN

L MidFG-SupFG

0.007

−0.28

−0.07

−0.21

ECN

L Sup-Inf PS

0.001

0.03

−0.06

−0.26

ECN

R Sup-Inf PS

0.001

0.12

0.10

−0.19

Salience

L Ant Insula

0.008

0.21

0.23

0.07

Salience

R Ant Insula

<0.001

0.30

0.37

0.10

Salience

R Thal-Insula

0.006

0.26

0.22

0.18

Salience

R IPL

0.004

0.12

0.26

−0.03

Sensorimotor

L Pre-postcentral

<0.001

0.35

0.22

0.30

Sensorimotor

R Pre-postcentral

<0.001

0.40

0.31

0.26

Visual

L Mid-Sup OG

0.009

0.12

0.21

0.27

Visual

Calcarine Sulc

0.008

0.26

0.08

0.20

Visual

L Front Oper/IFG

0.009

−0.17

0.06

−0.18

Visual

RIPL

0.007

−0.06

0.22

0.02

Visual

R MTG

<0.001

0.20

c

Network Domain

Label

Omnibus p-value (FDR adjusted)

BP

SAD

SZ

Auditory

L STG

<0.001

0.30

0.31

0.36

Auditory

R STG

<0.001

0.32

0.37

0.36

Salience

R Ant Insula

0.005

0.15

0.32

0.25

Sensorimotor

L Pre-postcentral

<0.001

0.26

0.16

0.42

Sensorimotor

R Pre-postcentral

<0.001

0.34

0.21

0.42

Visual

R MTG

<0.001

0.29

0.39

0.20

  1. Blue cells indicate hypoconnectivity and red hyperconnectivity in patient groups. The brighter the cell color the higher the effect size. Numbers within patient cells indicate corresponding Cohens d effect sizes. Bolded values were significant at p < 0.05 (Sidak corrected for multiple comparisons).
  2. BG basal ganglia, DMN default mode network, ECN executive control network.
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